Cochrane · systematic review · CD008475
Gonadotrophin‐releasing hormone analogues for pain associated with endometriosis
Veth, VB, van de Kar, MMA, McDonnell, R, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
GnRHas compared to No treatment for pain associated with endometriosis
Population: women with pain associated with endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relief of painful symptoms ‐ Dysmenorrhoea GnRHas vs No treatment | RR 3.93 [1.37, 11.28] | 1 study · 35 participants | Low Downgraded: risk of bias |
GnRHas compared to Placebo for pain associated with endometriosis
Population: women with pain associated with endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relief of painful symptoms ‐ pelvic tenderness GnRHas vs Placebo | RR 4.17 [1.62, 10.68] | 1 study · 49 participants | Low Downgraded: risk of bias |
Pain score ‐ Overall at 4 weeks GnRHas vs Placebo | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias |
GnRHas compared to Danazol for women with pain due to endometriosis
Population: women with pain due to endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relief of painful symptoms ‐ Dysmenorrhoea GnRHas vs Danazol | RR 0.98 [0.92, 1.04] | 7 studies · 666 participants | Very low Downgraded: risk of bias, inconsistency |
Overall resolution ‐ Overall resolution/improvement GnRHas vs Danazol | RR 1.1 [1.01, 1.21] | 9 studies · 1046 participants | Low Downgraded: risk of bias |
GnRHas compared to intra‐ uterine progestogen device for pain associated with endometriosis
Population: women with pain associated with endometriosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relief of painful symptoms ‐ Overall GnRHas vs intra‐ uterine progestogen device | no estimate extracted | 3 studies · 129 participants | Moderate Downgraded: risk of bias |