Cochrane · systematic review · CD008331
Tocilizumab for rheumatoid arthritis
Singh, JA, Beg, S, Lopez‐Olivo, MA · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 4 · 57.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tocilizumab 8 mg/kg + MTX/DMARD versus placebo + MTX/DMARD for rheumatoid arthritis
Population: patients with rheumatoid arthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ACR50% improvement criteria Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 3.17 [2.72, 3.67] | 4 studies · 2063 participants | High |
DAS Remission defined as DAS28 <2.6 Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 8.74 [6.26, 11.8] | 4 studies · 1946 participants | High |
HAQ improvement of >0.3 or MHAQ decrease of >0.22 (changes exceeding MCID) Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 1.79 [1.62, 1.94] | 1 study · 1220 participants | High |
Serious Adverse Events Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 1.17 [0.83, 1.64] | 3 studies · 1961 participants | Moderate Downgraded: risk of bias, inconsistency |
Total withdrawals Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 0.61 [0.49, 0.77] | 4 studies · 2064 participants | Moderate Downgraded: risk of bias, inconsistency |
Withdrawals due to Adverse events Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | RR 1.43 [0.95, 2.12] | 4 studies · 2064 participants | High |
Radiographic Progression Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + MTX/DMARD | no estimate extracted | 0 studies · 4 participants | Ungraded |