Cochrane · systematic review · CD008046
Gonadotropin‐releasing hormone agonist versus HCG for oocyte triggering in antagonist‐assisted reproductive technology
Youssef, MAFM, Van der Veen, F, Al‐Inany, HG, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGnRH agonist compared with HCG for oocyte maturation triggering in antagonist‐assisted reproductive technology
Population: subfertile women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth GnRH agonist vs HCG | OR 0.47 [0.31, 0.7] | 5 studies · 532 participants | Moderate Downgraded: risk of bias |
OHSS (mild, moderate or severe): overall risk GnRH agonist vs HCG | OR 0.15 [0.05, 0.47] | 8 studies · 989 participants | Moderate Downgraded: risk of bias, inconsistency |
OHSS (moderate or severe): overall risk GnRH agonist vs HCG | OR 0.21 [0.07, 0.66] | 8 studies · 989 participants | Moderate Downgraded: risk of bias, inconsistency |
OHSS (mild, moderate or severe) in women at high risk of OHSS GnRH agonist vs HCG | OR 0.06 [0.01, 0.34] | 3 studies · 212 participants | Moderate Downgraded: risk of bias, inconsistency |
Ongoing pregnancy GnRH agonist vs HCG | OR 0.7 [0.54, 0.91] | 11 studies · 1198 participants | Low Downgraded: risk of bias, inconsistency |
Miscarriage GnRH agonist vs HCG | OR 1.74 [1.1, 2.75] | 11 studies · 1198 participants | Moderate Downgraded: risk of bias, inconsistency |
GnRH agonist compared to HCG for final oocyte maturation triggering in GnRH antagonist down‐regulated cycles
Population: GnRH antagonist downregulated cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate GnRH agonist vs HCG | OR 0.44 [0.29, 0.68] | 8 studies · 497 participants | High |
OHSS incidence GnRH agonist vs HCG | OR 0.1 [0.01, 0.82] | 5 studies · 504 participants | High |
GnRH agonist compared to HCG for final oocyte maturation triggering in GnRH antagonist down‐regulated cycles
Population: GnRH antagonist downregulated cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate GnRH agonist vs HCG | OR 0.44 [0.29, 0.68] | 8 studies · 497 participants | High |
OHSS incidence GnRH agonist vs HCG | OR 0.1 [0.01, 0.82] | 5 studies · 504 participants | High |