Cochrane · systematic review · CD007911
Cryotherapy following total knee replacement
Aggarwal, A, Adie, S, Harris, IA, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAny cold therapy compared with no cold therapy following total knee replacement
Population: people undergoing total knee replacement
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood lossTime point: mean 48 hours, range 1 to 13 days. Higher blood loss indicates a worse outcome. Any cold therapy vs no cold therapy following total knee replacement | no estimate extracted | 12 studies · 956 participants | Low Downgraded: risk of bias, inconsistency |
Pain at post‐operative day 2Scale from 0 (best) to 10 (worst). Any cold therapy vs no cold therapy following total knee replacement | no estimate extracted | 6 studies · 530 participants | Low Downgraded: risk of bias |
Transfusion rate Any cold therapy vs no cold therapy following total knee replacement | RR 2.13 [0.04, 109.63] | 2 studies · 91 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Range of motion at dischargeScale from 0 (worst) to 125 (best). Any cold therapy vs no cold therapy following total knee replacement | no estimate extracted | 3 studies · 174 participants | Low Downgraded: risk of bias, indirectness |
Function Standardised scale with positive score indicating a better outcome. Scale from 0 (worst) to 100 (best). Any cold therapy vs no cold therapy following total knee replacement | no estimate extracted | 4 studies · 296 participants | Very low Downgraded: risk of bias, inconsistency |
Total adverse eventsAdverse events included discomfort, local skin reactions, superficial infections, cold‐induced injuries and thrombolytic events. Any cold therapy vs no cold therapy following total knee replacement | RR 1.3 [0.53, 3.2] | 16 studies · 1199 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Withdrawals due to adverse events Any cold therapy vs no cold therapy following total knee replacement | RR 2.71 [0.42, 17.38] | 19 studies · 1347 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Any cold therapy compared to any control for patients undergoing total knee replacement
Population: patients with patients undergoing total knee replacement
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss Any cold therapy vs any control | no estimate extracted | 10 studies · 666 participants | Very low Downgraded: risk of bias |
Pain at post‐operative day 2 Scale from: 0 to 10. Any cold therapy vs any control | no estimate extracted | 4 studies · 322 participants | Very low Downgraded: risk of bias |
Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events Any cold therapy vs any control | RR 0.98 [0.28, 3.47] | 11 studies · 675 participants | Very low Downgraded: risk of bias |
Range of motion at discharge Scale from: 0 to 125. Any cold therapy vs any control | no estimate extracted | 2 studies · 107 participants | Low Downgraded: risk of bias |
Transfusion rate Any cold therapy vs any control | RR 2.13 [0.04, 109.63] | 2 studies · 91 participants | Very low Downgraded: risk of bias, imprecision |
Function ‐ not measured Any cold therapy vs any control | no estimate extracted | NR | No studies |