evidence/gaps
Cochrane · systematic review · CD007514

Statins for the treatment of dementia

McGuinness, B, Craig, D, Bullock, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library

Dementia and Cognitive Improvement2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 4 · 100%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Statins compared with placebo for the treatment of dementia

CD007514.PUB3 (current) · 4 questions
OutcomeEffectEvidenceStatus / GRADE
Change in ADAS‐Cog
Statins vs placebo
no estimate extracted4 studies · 1110 participantsHigh
Change in MMSE
Statins vs placebo
no estimate extracted4 studies · 1127 participantsHigh
Change in CGIC
Statins vs placebo
no estimate extracted2 studies · 660 participantsHigh
Change in NPI
Statins vs placebo
no estimate extracted3 studies · 983 participantsHigh

Statins Compared to Placebo for the Treatment of Dementia

CD007514.PUB2 · 4 questions
OutcomeEffectEvidenceStatus / GRADE
Change in ADAS‐Cog
Statins vs Placebo
no estimate extracted3 studies · 704 participantsHigh
Change in MMSE
Statins vs Placebo
no estimate extracted3 studies · 721 participantsHigh
Change in CGIC
Statins vs Placebo
no estimate extracted2 studies · 660 participantsHigh
Change in NPI
Statins vs Placebo
no estimate extracted2 studies · 577 participantsHigh