Cochrane · systematic review · CD007411
Antioxidants for male subfertility
de Ligny, W, Smits, RM, Mackenzie-Proctor, R, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntioxidants compared to placebo or no treatment for patients with male subfertility
Population: patients with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple randomised Antioxidants vs placebo or no treatment | OR 1.43 [1.07, 1.91] | 12 studies · 1283 participants | Very low Downgraded: risk of bias |
Clinical pregnancy rate per couple randomised Antioxidants vs placebo or no treatment | OR 1.89 [1.45, 2.47] | 20 studies · 1706 participants | Low Downgraded: risk of bias |
Adverse events ‐ Miscarriage Antioxidants vs placebo or no treatment | OR 1.46 [0.75, 2.83] | 6 studies · 664 participants | Very low Downgraded: risk of bias |
Adverse events ‐ Gastrointestinal Antioxidants vs placebo or no treatment | OR 2.7 [1.46, 4.99] | 16 studies · 1355 participants | Low Downgraded: risk of bias |
Antioxidants compared to placebo or no treatment for patients with male subfertility
Population: patients with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple randomised Antioxidants vs placebo or no treatment | OR 1.79 [1.2, 2.67] | 7 studies · 750 participants | Low Downgraded: risk of bias |
Clinical pregnancy rate per couple randomised Antioxidants vs placebo or no treatment | OR 2.97 [1.91, 4.63] | 11 studies · 786 participants | Low Downgraded: risk of bias |
Adverse events ‐ Miscarriage Antioxidants vs placebo or no treatment | OR 1.74 [0.4, 7.6] | 3 studies · 247 participants | Very low Downgraded: risk of bias |
Adverse events ‐ Gastrointestinal Antioxidants vs placebo or no treatment | OR 2.51 [1.25, 5.03] | 11 studies · 948 participants | Very low Downgraded: risk of bias |
Antioxidants versus placebo or no treatment for male subfertility
Population: patients with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live Birth per couple randomised Antioxidants vs placebo or no treatment | OR 4.21 [2.08, 8.51] | 4 studies · 277 participants | Low Downgraded: imprecision |
Clinical Pregnancy rate per couple randomised Antioxidants vs placebo or no treatment | OR 3.43 [1.92, 6.11] | 7 studies · 522 participants | Low Downgraded: imprecision |
Adverse event: Miscarriage rate per couple randomised Antioxidants vs placebo or no treatment | OR 1.74 [0.4, 7.6] | 3 studies · 247 participants | Very low Downgraded: imprecision |
Antioxidant/s versus control for male subfertility
Population: patients with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live Birth per couple randomised Antioxidant/s vs control | OR 4.85 [1.92, 12.24] | 3 studies · 214 participants | Very low Downgraded: imprecision |
Pregnancy rate per couple randomised Antioxidant/s vs control | OR 4.18 [2.65, 6.59] | 15 studies · 964 participants | Very low |
Adverse event: Miscarriage rate per couple randomised Antioxidant/s vs control | OR 1.54 [0.32, 7.3] | 3 studies · 242 participants | Very low Downgraded: inconsistency |