Cochrane · systematic review · CD007337

Intraperitoneal local anaesthetic instillation versus no intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy

Rutherford, D, Massie, EM, Worsley, C, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Hepato-Biliary2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 14.3%Ungraded 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table ‐ Intraperitoneal local anaesthetic compared to control for patients undergoing laparoscopic cholecystectomy

Population: patients undergoing laparoscopic cholecystectomy

CD007337.PUB4 (current) · 7 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	no estimate extracted	8 studies · 446 participants	Very low Downgraded: risk of bias, imprecision
Serious adverse events Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	RR 1.07 [0.49, 2.34]	13 studies · 988 participants	Very low Downgraded: risk of bias, imprecision
Health related quality of life ‐ not measured Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	no estimate extracted	NR	No studies
Hospital stay Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	no estimate extracted	12 studies · 936 participants	Moderate Downgraded: risk of bias
Proportion discharged as day surgery Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	RR 1.43 [0.64, 3.2]	3 studies · 242 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Pain (4 to 8 hours)Scale from: 1 to 10 Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	no estimate extracted	57 studies · 4046 participants	Low Downgraded: risk of bias, inconsistency
Pain (9 to 24 hours)Scale from: 1 to 10 Summary of findings table ‐ Intraperitoneal local anaesthetic vs control	no estimate extracted	52 studies · 3588 participants	Low Downgraded: risk of bias, inconsistency

Intraperitoneal local anaesthetic instillation compared with control for people undergoing laparoscopic cholecystectomy

Population: people undergoing laparoscopic cholecystectomy.

CD007337.PUB3 · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality Intraperitoneal local anaesthetic instillation vs control	no estimate extracted	8 studies · 446 participants	Very low Downgraded: risk of bias
Serious adverse events Intraperitoneal local anaesthetic instillation vs control	RR 3 [0.13, 67.06]	8 studies · 446 participants	Very low Downgraded: risk of bias
Proportion discharged as day surgery Intraperitoneal local anaesthetic instillation vs control	RR 1.25 [0.99, 1.58]	3 studies · 242 participants	Very low Downgraded: risk of bias, inconsistency
Hospital stay Intraperitoneal local anaesthetic instillation vs control	no estimate extracted	5 studies · 335 participants	Low Downgraded: risk of bias
Pain (4 to 8 hours) Intraperitoneal local anaesthetic instillation vs control	no estimate extracted	32 studies · 2020 participants	Very low Downgraded: risk of bias, inconsistency
Pain (9 to 24 hours) Intraperitoneal local anaesthetic instillation vs control	no estimate extracted	29 studies · 1787 participants	Very low Downgraded: risk of bias, inconsistency