Cochrane · systematic review · CD007323
Doxycycline for osteoarthritis of the knee or hip
da Costa, BR, Nüesch, E, Reichenbach, S, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: participants with osteoarthritis of the knee or hip
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain 10‐cm VAS scale (median | no estimate extracted | 2 studies · 524 participants | Moderate Downgraded: risk of bias, imprecision |
Function WOMAC function (range 0 to 10) (median | no estimate extracted | 2 studies · 517 participants | Moderate Downgraded: risk of bias, imprecision |
Minimum joint space width ( | no estimate extracted | 1 study · 361 participants | Moderate Downgraded: risk of bias, imprecision |
Number of participants experiencing any adverse event ( | RR 1.36 [1.08, 1.72] | 1 study · 232 participants | Low Downgraded: risk of bias, imprecision |
Number of participants withdrawn due to adverse events (median | RR 2.28 [1.06, 4.9] | 2 studies · 663 participants | Low Downgraded: risk of bias, imprecision |
Number of participants experiencing any serious adverse event (median | RR 1.07 [0.68, 1.68] | 2 studies · 663 participants | Low Downgraded: risk of bias, imprecision |
Comparison
Population: Patients with osteoarthritis of the knee or hip
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain 10 cm VAS scale ( | no estimate extracted | 1 study · 307 participants | Low |
Function WOMAC function (range 17 to 85) ( | no estimate extracted | 1 study · 307 participants | Low |
Minimum joint space width ( | no estimate extracted | 1 study · 361 participants | Moderate |
Number of patients withdrawn due to adverse events ( | RR 1.69 [1.03, 2.75] | 1 study · 431 participants | Moderate |
Number of patients experiencing any serious adverse event ( | RR 1.04 [0.65, 1.67] | 1 study · 431 participants | Low |