Cochrane · systematic review · CD007245
Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen
Romero, SAD, Young, K, Hickey, M, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyThe LNG‐IUS with endometrial surveillance compared to endometrial surveillance alone for endometrial protection in women with breast cancer on adjuvant tamoxifen
Population: women with breast cancer on adjuvant tamoxifen
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial polyps The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.22 [0.13, 0.39] | 4 studies · 417 participants | Moderate Downgraded: imprecision |
Endometrial hyperplasia The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.13 [0.03, 0.67] | 4 studies · 417 participants | Moderate Downgraded: imprecision |
Endometrial cancer The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | no estimate extracted | 2 studies · 154 participants | Moderate Downgraded: imprecision |
Fibroids The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.48 [0.16, 1.46] | 3 studies · 314 participants | Moderate Downgraded: imprecision |
Abnormal vaginal bleeding or spotting The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 7.26 [3.37, 15.66] | 3 studies · 376 participants | Moderate Downgraded: imprecision |
Breast cancer recurrence The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 1.74 [0.64, 4.74] | 2 studies · 154 participants | Moderate Downgraded: imprecision |
Breast cancer‐related death The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 1.02 [0.36, 2.84] | 3 studies · 277 participants | Moderate Downgraded: imprecision |
The LNG‐IUS with endometrial surveillance compared to endometrial surveillance alone for endometrial protection in women with breast cancer on adjuvant tamoxifen
Population: endometrial protection in women with breast cancer on adjuvant tamoxifen
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial Polyps The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.22 [0.13, 0.39] | 4 studies · 417 participants | Moderate Downgraded: imprecision |
Endometrial Hyperplasia The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.13 [0.03, 0.67] | 4 studies · 417 participants | Moderate Downgraded: imprecision |
Endometrial Cancer The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | no estimate extracted | 2 studies · 154 participants | Moderate Downgraded: imprecision |
Fibroids The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 0.48 [0.16, 1.46] | 3 studies · 314 participants | Moderate Downgraded: imprecision |
Abnormal Vaginal Bleeding or Spotting The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 7.26 [3.37, 15.66] | 3 studies · 376 participants | Moderate Downgraded: imprecision |
Abnormal Vaginal Bleeding or Spotting The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 2.72 [1.04, 7.1] | 2 studies · 233 participants | Moderate Downgraded: imprecision |
Abnormal Vaginal Bleeding or Spotting The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | no estimate extracted | 1 study · 94 participants | Moderate Downgraded: imprecision |
Breast Cancer Recurrence The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 1.74 [0.64, 4.74] | 2 studies · 154 participants | Moderate Downgraded: imprecision |
Breast Cancer‐related Death The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone | OR 1.02 [0.36, 2.84] | 3 studies · 277 participants | Moderate Downgraded: imprecision |