Cochrane · systematic review · CD006980
Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries
Haider, BA, Sharma, R, Bhutta, ZA · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 1 · 12.5%Moderate 0 · 0%High 6 · 75%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyNeonatal vitamin A supplementation versus control for prevention of mortality and morbidity in term neonates in low and middle income countries
Population: mortality and morbidity in term neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause infant mortality at 6 months: risk ratios based on cumulative risk (%, adjusted for clustering) ‐ term infants Neonatal vitamin A supplementation vs control | RR 0.8 [0.54, 1.18] | 3 studies · 22721 participants | Very low Downgraded: risk of bias |
All‐cause infant mortality at 6 months: risk ratios based on cumulative risk (%, adjusted for clustering) ‐ all infants Neonatal vitamin A supplementation vs control | RR 0.98 [0.89, 1.07] | 11 studies · 154634 participants | High |
All‐cause neonatal mortality: risk ratios based on cumulative risk (%, adjusted for clustering) ‐ all infants Neonatal vitamin A supplementation vs control | RR 0.99 [0.9, 1.08] | 5 studies · 126242 participants | High |
Adverse events during first 48‐72 hours post supplementation ‐ bulging fontanelle Neonatal vitamin A supplementation vs control | RR 1.53 [1.11, 2.11] | 5 studies · 100256 participants | High |
Adverse events during first 48‐72 hours post supplementation ‐ vomiting Neonatal vitamin A supplementation vs control | RR 1 [0.93, 1.07] | 5 studies · 99582 participants | High |
Adverse events during first 48‐72 hours post supplementation ‐ diarrhoea Neonatal vitamin A supplementation vs control | RR 0.96 [0.81, 1.13] | 5 studies · 102638 participants | Low Downgraded: risk of bias, inconsistency |
Vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of age Neonatal vitamin A supplementation vs control | RR 0.94 [0.75, 1.19] | 1 study · 612 participants | High |
Vitamin A deficiency (serum retinol < 0.70 micromol/L) at 4 months of age Neonatal vitamin A supplementation vs control | RR 1.02 [0.64, 1.62] | 1 study · 369 participants | High |
Neonatal vitamin A supplementation versus control for the prevention of mortality and morbidity in term neonates in developing countries
Population: mortality and morbidity in term neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All cause infant mortality at 6 months Neonatal vitamin A supplementation vs control | RR 0.82 [0.68, 0.99] | 3 studies · 22721 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
All cause infant mortality at 12 months child years of Neonatal vitamin A supplementation vs control | Rate ratio 0.95 [0.72, 1.26] | 2 studies · 5732 participants | Low Downgraded: risk of bias, inconsistency, publication bias |
Adverse events: Bulging fontanelle Neonatal vitamin A supplementation vs control | RR 1.38 [1.04, 1.82] | 2 studies · 3158 participants | High |
Adverse events: Vomiting Neonatal vitamin A supplementation vs control | RR 0.88 [0.74, 1.05] | 2 studies · 3159 participants | Moderate |
Adverse events: Diarrhoea Neonatal vitamin A supplementation vs control | RR 0.92 [0.77, 1.09] | 2 studies · 3159 participants | Moderate Downgraded: inconsistency |