Cochrane · systematic review · CD006870
Statins for acute coronary syndrome
Vale, N, Nordmann, AJ, Schwartz, GG, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyStatins compared to control at 4 months (3 to 6 months) for acute coronary syndrome
Population: patients with acute coronary syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Combined outcome of non‐fatal myocardial infarction, non‐fatal stroke, and total number of deaths Statins vs control at 4 months (3 to 6 months) | RR 0.93 [0.81, 1.06] | 11 studies · 9625 participants | Moderate Downgraded: risk of bias, imprecision |
Death from all causes Statins vs control at 4 months (3 to 6 months) | RR 0.9 [0.7, 1.14] | 12 studies · 9733 participants | Moderate Downgraded: risk of bias, imprecision |
Fatal and non‐fatal myocardial infarction or reinfarction Statins vs control at 4 months (3 to 6 months) | RR 0.91 [0.77, 1.06] | 10 studies · 9537 participants | Moderate Downgraded: risk of bias, imprecision |
Fatal and non‐fatal stroke Statins vs control at 4 months (3 to 6 months) | RR 0.72 [0.45, 1.16] | 7 studies · 8536 participants | Moderate Downgraded: risk of bias, imprecision |
Unstable angina Statins vs control at 4 months (3 to 6 months) | RR 0.76 [0.59, 0.96] | 9 studies · 8770 participants | Moderate Downgraded: risk of bias, inconsistency |
Acute heart failure Statins vs control at 4 months (3 to 6 months) | RR 0.86 [0.65, 1.15] | 2 studies · 7583 participants | Moderate Downgraded: risk of bias, imprecision |
Rhabdomyolysis Statins vs control at 4 months (3 to 6 months) | RR 6.9 [0.36, 133.47] | 1 study · 4497 participants | Low Downgraded: imprecision |
Statins compared to Control at 4 months (3 ‐ 6 months) for acute coronary syndrome
Population: patients with acute coronary syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Combined outcome of nonfatal myocardial infarction, nonfatal stroke, and total number of deaths Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.93 [0.81, 1.06] | 11 studies · 9625 participants | Moderate Downgraded: risk of bias, imprecision |
Death from all causes Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.9 [0.7, 1.14] | 12 studies · 9733 participants | Moderate Downgraded: risk of bias, imprecision |
Fatal & Nonfatal myocardial infarction or reinfarction Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.91 [0.77, 1.06] | 10 studies · 9537 participants | Moderate Downgraded: risk of bias, imprecision |
Fatal and nonfatal stroke Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.72 [0.45, 1.16] | 7 studies · 8536 participants | Moderate Downgraded: risk of bias, imprecision |
Unstable angina Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.76 [0.59, 0.96] | 9 studies · 8770 participants | Moderate Downgraded: risk of bias, inconsistency |
Acute Heart Failure Statins vs Control at 4 months (3 ‐ 6 months) | RR 0.86 [0.65, 1.15] | 2 studies · 7583 participants | Moderate Downgraded: risk of bias, imprecision |
Rhabdomyolysis Statins vs Control at 4 months (3 ‐ 6 months) | RR 6.9 [0.36, 133.47] | 1 study · 4497 participants | Low Downgraded: imprecision |