Cochrane · systematic review · CD006237

Interventions to improve return to work in depressed people

Nieuwenhuijsen, K, Verbeek, JH, Neumeyer-Gromen, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

Work2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
15
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 6.7%Low 7 · 46.7%Moderate 6 · 40%High 1 · 6.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Work‐directed plus clinical intervention compared to care as usual in depressed people, medium‐term follow‐up

4 questions
OutcomeEffectEvidenceStatus / GRADE
Sickness absence days
Work‐directed plus clinical intervention vs care
no estimate extracted9 studies · 1292 participantsModerate
Downgraded: risk of bias
On sick leave
Work‐directed plus clinical intervention vs care
RR 1.08 [0.64, 1.83]2 studies · 1025 participantsHigh
Depressive symptoms‐
Work‐directed plus clinical intervention vs care
no estimate extracted8 studies · 1091 participantsLow
Downgraded: risk of bias, imprecision, inconsistency
Work functioning
Work‐directed plus clinical intervention vs care
no estimate extracted5 studies · 926 participantsLow
Downgraded: risk of bias

Work‐directed intervention compared to care as usual in depressed people, medium‐term follow‐up

Population: Depressed persons
4 questions
OutcomeEffectEvidenceStatus / GRADE
Sickness absence days, medium‐term
Work‐directed intervention vs care
no estimate extracted2 studies · 130 participantsLow
Downgraded: risk of bias, imprecision
Off work, medium‐term
Work‐directed intervention vs care
RR 0.93 [0.77, 1.11]1 study · 226 participantsModerate
Downgraded: risk of bias, imprecision
Depressive symptoms, medium‐term
Work‐directed intervention vs care
no estimate extracted4 studies · 390 participantsModerate
Downgraded: risk of bias, imprecision
Work functioning, medium‐term
Work‐directed intervention vs care
no estimate extracted1 study · 48 participantsLow
Downgraded: risk of bias, imprecision

Psychological intervention compared to care as usual in depressed people, medium‐term follow‐up

Population: Depressed persons
3 questions
OutcomeEffectEvidenceStatus / GRADE
Sickness absence days, medium‐term
Psychological intervention vs care
no estimate extracted9 studies · 1649 participantsLow
Downgraded: risk of bias
Depressive symptoms, medium‐term
Psychological intervention vs care
no estimate extracted8 studies · 1255 participantsLow
Downgraded: risk of bias, imprecision, publication bias
Work ability, medium‐term
Psychological intervention vs care
no estimate extracted1 study · 58 participantsVery low
Downgraded: risk of bias, imprecision, publication bias

Improved care compared to care as usual in depressed people, medium‐term follow‐up

Population: Depressed persons
4 questions
OutcomeEffectEvidenceStatus / GRADE
Sickness absence days, medium‐term
Improved care vs care
no estimate extracted7 studies · 1912 participantsModerate
Downgraded: risk of bias, imprecision
Off work, medium‐term
Improved care vs care
RR 0.97 [0.77, 1.22]1 study · 362 participantsLow
Downgraded: risk of bias, imprecision
Depressive symptoms, medium‐term
Improved care vs care
no estimate extracted7 studies · 1808 participantsModerate
Downgraded: risk of bias, imprecision
Work functioning, medium‐term
Improved care vs care
no estimate extracted1 study · 604 participantsModerate
Downgraded: risk of bias, imprecision