Cochrane · systematic review · CD006086
Nutritional supplements for people being treated for active tuberculosis
Grobler, L, Nagpal, S, Sudarsanam, TD, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 16.7%Very low 6 · 50%Low 3 · 25%Moderate 1 · 8.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version only'Summary of findings' table 1
Population: adults and children with active tuberculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (at 6 months) | RR 0.34 [0.1, 1.2] | 4 studies · 567 participants | Very low Downgraded: imprecision, indirectness |
Cured (at 6 months) | RR 0.91 [0.59, 1.41] | 1 study · 102 participants | Very low Downgraded: imprecision, indirectness |
Treatment completion (at 6 months) | no estimate extracted | 2 studies · 365 participants | Very low Downgraded: imprecision, inconsistency |
Sputum negative (at 8 weeks) | RR 1.08 [0.86, 1.37] | 3 studies · 222 participants | Very low Downgraded: imprecision, inconsistency |
Mean weight gain (At 8 weeks) | no estimate extracted | 5 studies · 883 participants | Moderate Downgraded: inconsistency |
Quality of life (At 8 weeks) | no estimate extracted | 2 studies · 134 participants | Low Downgraded: imprecision, indirectness |
'Summary of findings' table 2
Population: adults and children with active tuberculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.86 [0.46, 1.6] | 4 studies · 1219 participants | Low Downgraded: imprecision, inconsistency |
Cure rate | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment completion | RR 0.99 [0.95, 1.04] | 1 study · 302 participants | Very low Downgraded: imprecision, indirectness |
Remaining sputum positive (at 4 weeks) | RR 0.92 [0.63, 1.35] | 2 studies · 1020 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Weight gain | no estimate extracted | 5 studies · 2940 participants | Low Downgraded: imprecision, inconsistency |
Quality of life | no estimate extracted | 0 studies · 0 participants | Ungraded |
Comparison
Population: adults and children with active tuberculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (at 6 months) | RR 0.4 [0.07, 2.25] | 2 studies · 202 participants | Very low Downgraded: imprecision, indirectness |
Cured (at 6 months) | RR 0.91 [0.59, 1.41] | 1 study · 102 participants | Very low Downgraded: imprecision, indirectness |
Treatment completion (at 6 months) | RR 1.08 [0.88, 1.33] | 2 studies · 365 participants | Very low Downgraded: imprecision, inconsistency |
Sputum negative (at 8 weeks) | RR 1.2 [1.02, 1.4] | 2 studies · 149 participants | Very low Downgraded: imprecision, inconsistency |
Mean weight gain (At 8 weeks) | no estimate extracted | 4 studies · 731 participants | Moderate Downgraded: inconsistency |
Quality of life (At 8 weeks) | no estimate extracted | 2 studies · 134 participants | Low Downgraded: imprecision, indirectness |
Comparison
Population: adults and children with active tuberculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.76 [0.41, 1.42] | 3 studies · 917 participants | Very low Downgraded: imprecision, inconsistency |
Cure rate | no estimate extracted | 0 studies · 0 participants | Ungraded |
Treatment completion | no estimate extracted | 0 studies · 0 participants | Ungraded |
Remaining sputum +ve (at 4 weeks) | RR 1.01 [0.85, 1.2] | 2 studies · 1020 participants | Low Downgraded: imprecision, inconsistency |
Weight gain | no estimate extracted | 5 studies · 3376 participants | Moderate Downgraded: imprecision, inconsistency |
Quality of life | no estimate extracted | 0 studies · 0 participants | Ungraded |