Cochrane · systematic review · CD006047
Household interventions for secondary prevention of domestic lead exposure in children
Nussbaumer-Streit, B, Mayr, V, Dobrescu, AI, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
8
No studies
7
Included studies
NR
No studies 7 · 46.7%Ungraded 0 · 0%Very low 4 · 26.7%Low 1 · 6.7%Moderate 3 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyEducation interventions versus no intervention for preventing domestic lead exposure in children
Population: children (aged 0–2 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive and neurobehavioural outcomes Education interventions vs no intervention | no estimate extracted | NR | No studies |
Adverse events Education interventions vs no intervention | no estimate extracted | NR | No studies |
Blood lead levels (continuous)Blood lead levels after intervention Scale: 0–30 Education interventions vs no intervention | no estimate extracted | 5 studies · 815 participants | Moderate Downgraded: risk of bias, imprecision |
Household dust: hard floor dust lead levels (continuous)Floor dust lead levels Scale: 0–40 Education interventions vs no intervention | no estimate extracted | 2 studies · 318 participants | Moderate Downgraded: imprecision |
Environmental interventions versus no intervention for preventing domestic lead exposure in children
Population: children (aged 0–6 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive and neurobehavioural outcomes Scale Wechsler IQ: BRIEF: Environmental interventions vs no intervention | no estimate extracted | 1 study · 224 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Environmental interventions vs no intervention | no estimate extracted | 1 study · 355 participants | Very low Downgraded: imprecision |
Blood lead levels (continuous)Blood lead level at end of duration Scale: 0–30 Environmental interventions vs no intervention | no estimate extracted | 4 studies · 565 participants | Moderate Downgraded: imprecision |
Household dust: floor dust lead levels Environmental interventions vs no intervention | no estimate extracted | NR | No studies |
Cognitive and neurobehavioural outcomes Environmental interventions vs no intervention | no estimate extracted | NR | No studies |
Adverse events Environmental interventions vs no intervention | no estimate extracted | NR | No studies |
Blood lead levels (continuous)Blood lead level at end of duration Scale: 0–30 Environmental interventions vs no intervention | no estimate extracted | 2 studies · 378 participants | Very low Downgraded: risk of bias, imprecision |
Combination interventions versus standard education for preventing domestic lead exposure in children
Population: children (aged 0–4 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive and neurobehavioural outcomes Combination interventions vs standard education | no estimate extracted | NR | No studies |
Adverse events Combination interventions vs standard education | no estimate extracted | NR | No studies |
Blood lead levels (continuous)Blood lead level at end of duration Scale: 0–30 Combination interventions vs standard education | no estimate extracted | 4 studies · 426 participants | Very low Downgraded: risk of bias, imprecision |
Household dust: floor dust lead levels Combination interventions vs standard education | no estimate extracted | 2 studies · 336 participants | Very low Downgraded: risk of bias, imprecision |
Education strategies versus no intervention for preventing domestic lead exposure in children
Population: children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive and neurobehavioural outcomes Education strategies vs no intervention | no estimate extracted | NR | No studies |
Adverse events Education strategies vs no intervention | no estimate extracted | NR | No studies |
Blood lead level (continuous) Blood lead levels after intervention Scale: 0‐30 Education strategies vs no intervention | no estimate extracted | 5 studies · 815 participants | High |
Blood lead level ≥ 10.0 µg/dL (dichotomous) Blood lead level Education strategies vs no intervention | RR 1.02 [0.79, 1.3] | 4 studies · 520 participants | Moderate Downgraded: imprecision |
Blood lead level ≥ 15.0 µg/dL (dichotomous) Blood lead level Education strategies vs no intervention | RR 0.6 [0.33, 1.09] | 4 studies · 520 participants | Moderate Downgraded: imprecision |
Floor dust ‐ hard floor (continuous) Floor dust lead levels Scale: 0‐40 Education strategies vs no intervention | no estimate extracted | 2 studies · 318 participants | Moderate Downgraded: imprecision |
Environmental strategies (dust control) versus no intervention for preventing domestic lead exposure in children
Population: children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive and neurobehavioural outcomes Environmental strategies (dust control) vs no intervention | no estimate extracted | NR | No studies |
Adverse events Environmental strategies (dust control) vs no intervention | no estimate extracted | NR | No studies |
Blood lead level (continuous) Blood lead level at end of duration Scale: 0‐30 Environmental strategies (dust control) vs no intervention | no estimate extracted | 3 studies · 298 participants | Low Downgraded: imprecision, inconsistency |
Blood lead level ≥ 10.0 µg/dL (dichotomous) Blood lead level Environmental strategies (dust control) vs no intervention | RR 0.93 [0.73, 1.18] | 2 studies · 210 participants | Moderate Downgraded: imprecision |
Blood lead level ≥ 15.0 µg/dL (dichotomous) Blood lead level Environmental strategies (dust control) vs no intervention | RR 0.86 [0.35, 2.07] | 2 studies · 210 participants | Low Downgraded: imprecision, inconsistency |
Education strategies for preventing domestic lead exposure in children
Population: Children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood lead level (continuous) Blood lead levels after intervention Scale from: 0 to 30 | no estimate extracted | 5 studies · 814 participants | High |
Blood lead level (dichotomous) ≥ 10 µg/dL blood lead level | RR 1.02 [0.79, 1.3] | 4 studies · 520 participants | Moderate |
Blood lead level (dichotomous) ≥ 15 µg/dL blood lead level | RR 0.6 [0.33, 1.09] | 4 studies · 520 participants | Moderate |
Floor dust ‐ hard floor (continuous) Floor dust lead levels Scale from: 0 to 40 | no estimate extracted | 2 studies · 318 participants | Moderate |
Cognitive and neurobehavioural outcomes ‐ not reported | no estimate extracted | NR | No studies |
Environmental strategies (dust control) for preventing domestic lead exposure in children
Population: Children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood lead level (continuous) Blood lead level at end of duration. Scale from: 0 to 30 | no estimate extracted | 3 studies · 298 participants | Moderate |
Blood lead level (dichotomous ≥ 10 µg/dL) blood lead level | RR 0.93 [0.73, 1.18] | 2 studies · 210 participants | Moderate |
Blood lead level (dichotomous ≥ 15 µg/dL) blood lead level | RR 0.86 [0.35, 2.07] | 3 studies · 210 participants | Moderate |
Cognitive and neurobehavioural outcomes ‐ not reported | no estimate extracted | NR | No studies |
Education strategies for preventing domestic lead exposure in children
Population: Children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood lead level (continuous) Blood lead levels after intervention Scale from: 0 to 30 | no estimate extracted | 5 studies · 814 participants | High |
Blood lead level (dichotomous) ≥ 10 µg/dL blood lead level | RR 1.02 [0.79, 1.3] | 4 studies · 520 participants | Moderate |
Blood lead level (dichotomous) ≥ 15 µg/dL blood lead level | RR 0.6 [0.33, 1.09] | 4 studies · 520 participants | Moderate |
Floor dust ‐ hard floor (continuous) Floor dust lead levels Scale from: 0 to 40 | no estimate extracted | 2 studies · 318 participants | Moderate |
Cognitive and neurobehavioural outcomes ‐ not reported | no estimate extracted | NR | No studies |
Environmental strategies (dust control) for preventing domestic lead exposure in children
Population: Children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood lead level (continuous) Blood lead level at end of duration. Scale from: 0 to 30 | no estimate extracted | 3 studies · 298 participants | Moderate |
Blood lead level (dichotomous ≥ 10 µg/dL) blood lead level | RR 0.93 [0.73, 1.18] | 2 studies · 210 participants | Moderate |
Blood lead level (dichotomous ≥ 15 µg/dL) blood lead level | RR 0.86 [0.35, 2.07] | 3 studies · 210 participants | Moderate |
Cognitive and neurobehavioural outcomes ‐ not reported | no estimate extracted | NR | No studies |