Cochrane · systematic review · CD005996
Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles
Boomsma, CM, Kamath, MS, Keay, SD, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 11 · 91.7%Low 1 · 8.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGlucocorticoids compared to no glucocorticoids or placebo for assisted reproductive technology cycles
Population: women receiving assisted reproductive technology cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple Glucocorticoids vs no glucocorticoids or placebo | OR 1.37 [0.69, 2.71] | 2 studies · 366 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of multiple pregnancies per couple Glucocorticoids vs no glucocorticoids or placebo | OR 0.86 [0.33, 2.2] | 4 studies · 504 participants | Very low Downgraded: risk of bias, imprecision |
Ongoing pregnancy rate per couple Glucocorticoids vs no glucocorticoids or placebo | OR 1.19 [0.8, 1.76] | 3 studies · 476 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple –pregnancy rate per couple (primary analysis) Glucocorticoids vs no glucocorticoids or placebo | OR 1.17 [0.95, 1.44] | 13 studies · 1967 participants | Low Downgraded: risk of bias |
Clinical pregnancy rate per couple – subgroup IVF Glucocorticoids vs no glucocorticoids or placebo | OR 1.44 [1, 2.08] | 5 studies · 724 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple – subgroup ICSI Glucocorticoids vs no glucocorticoids or placebo | OR 1.08 [0.81, 1.42] | 6 studies · 992 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: lower dose glucocorticoids Glucocorticoids vs no glucocorticoids or placebo | OR 1.2 [0.87, 1.67] | 6 studies · 780 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: higher dose glucocorticoids Glucocorticoids vs no glucocorticoids or placebo | OR 1.15 [0.87, 1.5] | 7 studies · 1187 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: glucocorticoids during implantation Glucocorticoids vs no glucocorticoids or placebo | OR 1.17 [0.9, 1.52] | 7 studies · 1246 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate per couple Glucocorticoids vs no glucocorticoids or placebo | OR 1.09 [0.63, 1.87] | 6 studies · 821 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of ectopic pregnancies per couple Glucocorticoids vs no glucocorticoids or placebo | OR 2.28 [0.33, 15.62] | 3 studies · 320 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of OHSS per couple (mild–severe) Glucocorticoids vs no glucocorticoids or placebo | OR 1.07 [0.6, 1.9] | 3 studies · 370 participants | Very low Downgraded: risk of bias, imprecision |
Comparison
Population: patients with infertility undergoing assisted reproductive technology cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple | OR 1.21 [0.67, 2.19] | 3 studies · 424 participants | Low Downgraded: risk of bias |
Ongoing pregnancy rate per couple | OR 1.15 [0.76, 1.75] | 3 studies · 429 participants | Low Downgraded: risk of bias |
Pregnancy rate per couple | OR 1.15 [0.93, 1.43] | 3 studies · 1759 participants | Moderate Downgraded: risk of bias |
Multiple pregnancy rate per couple | OR 2.02 [0.8, 5.11] | 4 studies · 372 participants | Moderate Downgraded: risk of bias |
Miscarriage rate per couple | OR 1.44 [0.82, 2.51] | 7 studies · 832 participants | Low Downgraded: risk of bias |
Ectopic pregnancy rate per couple | OR 2.28 [0.33, 15.62] | 4 studies · 407 participants | Low Downgraded: risk of bias, imprecision |
Incidence of OHSS per couple (mild‐severe) | OR 0.82 [0.33, 2.02] | 2 studies · 151 participants | Low Downgraded: risk of bias, imprecision |