Cochrane · systematic review · CD005993
Procaine treatments for cognition and dementia
Szatmári, S, Bereczki, D · Cochrane Database of Systematic Reviews · 2008 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
procaine compared to placebo for cognitive enhancement and dementia
Population: "healthy" old persons and demented women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
cognitive function improvement in "healthy" elderly persons Wechsler's memory scale2 procaine vs placebo | OR 12.71 [3.81, 42.42] | 1 study · 81 participants | Low |
cognitive function improvement in demented women Wechsler's memory scale2 procaine vs placebo | OR 0.04 [0, 1.12] | 1 study · 12 participants | Very low Downgraded: imprecision |
overall changes from baseline in "healthy persons7 ‐ not measured procaine vs placebo | no estimate extracted | NR | No studies |
overall changes from baseline in demented women procaine vs placebo | OR 0.04 [0, 0.83] | 1 study · 12 participants | Very low Downgraded: imprecision |
total adverse events in "healthy" persons procaine vs placebo | OR 7.3 [2.13, 25.02] | 2 studies · 415 participants | Low |