Cochrane · systematic review · CD005496
Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Sharif, S, Meader, N, Oddie, SJ, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 62.5%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyProbiotics compared to control in very preterm or very low birth weight infants
Population: very preterm or very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis (before hospital discharge) Probiotics vs control | no estimate extracted | 57 studies · 10918 participants | Low Downgraded: risk of bias, publication bias |
All‐cause mortality (before hospital discharge) Probiotics vs control | no estimate extracted | 54 studies · 10484 participants | Moderate Downgraded: risk of bias |
Late‐onset invasive infection (before hospital discharge) Probiotics vs control | no estimate extracted | 49 studies · 9876 participants | Moderate Downgraded: risk of bias |
Neurodevelopmental impairment (18 months to 3 years) Probiotics vs control | no estimate extracted | 5 studies · 1518 participants | Low Downgraded: risk of bias, imprecision |
Probiotics compared to control in extremely preterm or extremely low birth weight infants
Population: extremely preterm or extremely low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis (before hospital discharge) Probiotics vs control | no estimate extracted | 10 studies · 1836 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality (before hospital discharge) Probiotics vs control | no estimate extracted | 7 studies · 1723 participants | Low Downgraded: risk of bias, imprecision |
Late‐onset invasive infection (before hospital discharge) Probiotics vs control | no estimate extracted | 7 studies · 1533 participants | Low Downgraded: risk of bias, imprecision |
Neurodevelopmental impairment (18 months to 3 years) Probiotics vs control | no estimate extracted | NR | No studies |
Probiotics compared to control in very preterm or very low birth weight infants
Population: very preterm or very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis (before hospital discharge) Probiotics vs control | RR 0.54 [0.45, 0.65] | 54 studies · 10604 participants | Low Downgraded: risk of bias |
Mortality (all‐cause before hospital discharge) Probiotics vs control | RR 0.76 [0.65, 0.89] | 51 studies · 10170 participants | Moderate Downgraded: risk of bias |
Invasive infection (before hospital discharge) Probiotics vs control | RR 0.89 [0.82, 0.97] | 47 studies · 9762 participants | Moderate Downgraded: risk of bias |
Severe neurodevelopmental impairment (18 months to 3 years) Probiotics vs control | RR 1.03 [0.84, 1.26] | 5 studies · 1518 participants | Low Downgraded: risk of bias |
Probiotics compared to control in extremely preterm or extremely low birth weight infants
Population: extremely preterm or extremely low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis (before hospital discharge) Probiotics vs control | RR 0.9 [0.68, 1.21] | 8 studies · 1712 participants | Low Downgraded: risk of bias |
Mortality (before hospital discharge) Probiotics vs control | RR 0.91 [0.71, 1.16] | 6 studies · 1661 participants | Low Downgraded: risk of bias |
Invasive infection (before hospital discharge) Probiotics vs control | RR 0.9 [0.76, 1.06] | 6 studies · 1471 participants | Low Downgraded: risk of bias |