Cochrane · systematic review · CD005494

Sildenafil for pulmonary hypertension in neonates

Kelly, LE, Ohlsson, A, Shah, PS · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Sildenafil compared with placebo for pulmonary hypertension in neonates

Population: pulmonary hypertension in neonates

CD005494.PUB4 (current) · 3 questions

Outcome	Effect	Evidence	Status / GRADE
PaO2 in mmHg (absolute values) After 24‐25 hours Sildenafil vs placebo	no estimate extracted	2 studies · 57 participants	Low Downgraded: imprecision
Change in oxygenation index After 24 hours of treatment Sildenafil vs placebo	no estimate extracted	1 study · 12 participants	Low Downgraded: imprecision
All‐cause mortality Sildenafil vs placebo	RR 0.2 [0.07, 0.56]	3 studies · 77 participants	Low Downgraded: imprecision

Sildenafil compared with active control for pulmonary hypertension in neonates

Population: pulmonary hypertension in neonates

CD005494.PUB4 (current) · 1 question

Outcome	Effect	Evidence	Status / GRADE
All‐cause mortality Sildenafil vs active control	RR 0.55 [0.05, 5.75]	1 study · 65 participants	Very low Downgraded: imprecision

Sildenafil plus iNO compared with placebo plus iNO for pulmonary hypertension in neonates

Population: pulmonary hypertension in neonates

CD005494.PUB4 (current) · 2 questions

Outcome	Effect	Evidence	Status / GRADE
All‐cause mortality Sildenafil plus iNO vs placebo plus iNO	RR 1.27 [0.26, 6.28]	1 study · 24 participants	Low Downgraded: imprecision
Length of stay in hospital (days) Sildenafil plus iNO vs placebo plus iNO	no estimate extracted	1 study · 24 participants	Low Downgraded: imprecision

Comparison

Population: Neonates with pulmonary hypertension

CD005494.PUB3 · 4 questions

Outcome	Effect	Evidence	Status / GRADE
All‐cause mortality	RR 0.2	3 studies · 77 participants	Moderate
Oxygenation index (absolute values) after 24 hours of treatment	no estimate extracted	3 studies · 76 participants	Moderate
Change in oxygenation index ‐ After 24 hours of treatment	no estimate extracted	1 study · 8 participants	Very low
Changes in PaO2 after 24 hours of treatment	MD 16	2 studies · 64 participants	Moderate