Cochrane · systematic review · CD005370
Antithrombin III for critically ill patients
Allingstrup, M, Wetterslev, J, Ravn, FB, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: critically ill participants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (subgroup analysis on bias risk) | RR 0.95 [0.88, 1.03] | 29 studies · 3882 participants | Moderate Downgraded: risk of bias |
Bleeding events | RR 1.58 [1.35, 1.84] | 11 studies · 3019 participants | Moderate Downgraded: risk of bias, imprecision |
Incidence of respiratory failure not present at admission | RR 0.93 [0.76, 1.14] | 6 studies · 2591 participants | Moderate Downgraded: risk of bias |
Duration of mechanical ventilation | no estimate extracted | 3 studies · 190 participants | Very low Downgraded: risk of bias, imprecision |
Length of stay in hospital | no estimate extracted | 4 studies · 202 participants | Very low Downgraded: risk of bias, imprecision |
Mean length of stay in ICU | no estimate extracted | 7 studies · 376 participants | Very low Downgraded: risk of bias |
Overall mortality among patients with severe sepsis & DIC | RR 0.95 [0.88, 1.03] | 12 studies · 2858 participants | Very low Downgraded: risk of bias |