Cochrane · systematic review · CD005044
Quinine for muscle cramps
El‐Tawil, S, Al Musa, T, Valli, H, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 33.3%Moderate 8 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyQuinine versus placebo for muscle cramps
Population: people with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks Quinine vs placebo | no estimate extracted | 13 studies · 952 participants | Low Downgraded: risk of bias, inconsistency |
Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) Quinine vs placebo | no estimate extracted | 7 studies · 666 participants | Moderate Downgraded: risk of bias, inconsistency |
Participants suffering major adverse events Quinine vs placebo | no estimate extracted | 18 studies · 1103 participants | Moderate |
Participants suffering minor adverse events Quinine vs placebo | no estimate extracted | 16 studies · 969 participants | Moderate |
Quinine versus vitamin E for muscle cramps
Population: people with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Low Downgraded: inconsistency |
Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Moderate |
Participants suffering major adverse events Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Moderate |
Participants suffering minor adverse events Quinine vs vitamin E | no estimate extracted | 2 studies · 483 participants | Moderate |
Quinine versus a quinine‐vitamin E combination (Q‐Vel) for muscle cramps
Population: people with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 2 studies · 486 participants | Low |
Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Low |
Participants suffering major adverse events Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Moderate |
Participants suffering minor adverse events Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Moderate |
Quinine for muscle cramps
Population: patients with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks | no estimate extracted | 13 studies · 952 participants | Moderate |
Cramp intensity (on 3‐point scale; 1=mild; 2=moderate; 3=severe) | no estimate extracted | 7 studies · 666 participants | Moderate |
Participants suffering major adverse events | no estimate extracted | 18 studies · 1103 participants | Moderate |
Participants suffering minor adverse events | no estimate extracted | 16 studies · 969 participants | Moderate |
Quinine versus vitamin E for muscle cramps
Population: patients with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Low Downgraded: inconsistency |
Cramp intensity (on 3‐point scale; 1=mild; 2=moderate; 3=severe) Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Moderate |
Participants suffering major adverse events Quinine vs vitamin E | no estimate extracted | 3 studies · 513 participants | Moderate |
Participants suffering minor adverse events Quinine vs vitamin E | no estimate extracted | 2 studies · 483 participants | Moderate |
Quinine versus a quinine‐vitamin E combination (Q‐Vel) for muscle cramps
Population: patients with muscle cramps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cramps over 2 weeks Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 2 studies · 486 participants | Low |
Cramp intensity (on 3‐point scale; 1=mild; 2=moderate; 3=severe) Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Low |
Participants suffering major adverse events Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Moderate |
Participants suffering minor adverse events Quinine vs a quinine‐vitamin E combination (Q‐Vel) | no estimate extracted | 3 studies · 510 participants | Moderate |