Cochrane · systematic review · CD004905
Multiple‐micronutrient supplementation for women during pregnancy
Keats, EC, Haider, BA, Tam, E, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 33.3%High 4 · 66.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMultiple micronutrients compared to control (iron with or without folic acid) for women during pregnancy
Population: women during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm births Multiple micronutrients vs control (iron with or without folic acid) | RR 0.95 [0.9, 1.01] | 18 studies · 91425 participants | Moderate Downgraded: publication bias |
Small‐for‐gestational age Multiple micronutrients vs control (iron with or without folic acid) | RR 0.92 [0.88, 0.97] | 17 studies · 57348 participants | Moderate Downgraded: publication bias |
Low birthweight Multiple micronutrients vs control (iron with or without folic acid) | RR 0.88 [0.85, 0.91] | 18 studies · 68801 participants | High |
Perinatal mortality Multiple micronutrients vs control (iron with or without folic acid) | RR 1 [0.9, 1.11] | 15 studies · 63922 participants | High |
Stillbirths Multiple micronutrients vs control (iron with or without folic acid) | RR 0.95 [0.86, 1.04] | 17 studies · 97927 participants | High |
Neonatal mortality Multiple micronutrients vs control (iron with or without folic acid) | RR 1 [0.89, 1.12] | 14 studies · 80964 participants | High |
Multiple micronutrients compared with control (iron and/or folic acid) for women during pregnancy
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm births Multiple micronutrients vs control (iron and/or folic acid) | RR 0.96 [0.9, 1.03] | 15 studies · 90892 participants | High |
Small‐for‐gestational age Multiple micronutrients vs control (iron and/or folic acid) | RR 0.92 [0.86, 0.98] | 14 studies · 67036 participants | Moderate Downgraded: inconsistency, publication bias |
Low birthweight Multiple micronutrients vs control (iron and/or folic acid) | RR 0.88 [0.85, 0.91] | 15 studies · 70044 participants | High |
Perinatal mortality Multiple micronutrients vs control (iron and/or folic acid) | RR 1.01 [0.91, 1.13] | 12 studies · 94780 participants | High |
Stillbirths Multiple micronutrients vs control (iron and/or folic acid) | RR 0.97 [0.87, 1.09] | 15 studies · 98808 participants | High |
Neonatal mortality Multiple micronutrients vs control (iron and/or folic acid) | RR 1.06 [0.92, 1.22] | 11 studies · 83103 participants | High |
Multiple micronutrients compared with control (iron and/or folic acid) for women during pregnancy
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm births Multiple micronutrients vs control (iron and/or folic acid) | RR 0.96 [0.9, 1.03] | 15 studies · 90892 participants | High |
Small‐for‐gestational age Multiple micronutrients vs control (iron and/or folic acid) | RR 0.92 [0.86, 0.98] | 14 studies · 67036 participants | Moderate Downgraded: inconsistency, publication bias |
Low birthweight Multiple micronutrients vs control (iron and/or folic acid) | RR 0.88 [0.85, 0.91] | 15 studies · 70044 participants | High |
Perinatal mortality Multiple micronutrients vs control (iron and/or folic acid) | RR 1.01 [0.91, 1.13] | 12 studies · 94780 participants | High |
Stillbirths Multiple micronutrients vs control (iron and/or folic acid) | RR 0.97 [0.87, 1.09] | 15 studies · 98808 participants | High |
Neonatal mortality Multiple micronutrients vs control (iron and/or folic acid) | RR 1.06 [0.92, 1.22] | 11 studies · 83103 participants | High |