Cochrane · systematic review · CD004829
Pain relief for women undergoing oocyte retrieval for assisted reproduction
Kwan, I, Wang, R, Pearce, E, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
47
current version
GRADE rated
23
No studies
24
Included studies
NR
No studies 24 · 51.1%Ungraded 0 · 0%Very low 19 · 40.4%Low 4 · 8.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyConscious sedation and analgesia (CSA) compared with CSA+acupuncture for women undergoing oocyte retrieval for assisted reproduction
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) vs CSA+acupuncture | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias |
Postoperative pain Conscious sedation and analgesia (CSA) vs CSA+acupuncture | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias |
Pregnancy Conscious sedation and analgesia (CSA) vs CSA+acupuncture | OR 0.61 [0.2, 1.86] | 1 study · 61 participants | Very low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) vs CSA+acupuncture | no estimate extracted | NR | No studies |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) vs CSA+acupuncture | OR 1.64 [0.46, 5.88] | 1 study · 62 participants | Very low Downgraded: risk of bias |
Postoperative complications Conscious sedation and analgesia (CSA) vs CSA+acupuncture | no estimate extracted | NR | No studies |
Conscious sedation and analgesia (CSA) compared with CSA + electro‐acupuncture for women undergoing oocyte retrieval for assisted reproduction
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias |
Postoperative pain Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias |
Pregnancy Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | OR 0.22 [0.07, 0.66] | 1 study · 61 participants | Very low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | no estimate extracted | NR | No studies |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | OR 1.09 [0.33, 3.58] | 1 study · 62 participants | Very low Downgraded: risk of bias |
Postoperative complications Conscious sedation and analgesia (CSA) vs CSA + electro‐acupuncture | no estimate extracted | NR | No studies |
Conscious sedation and analgesia compared with general analgesia for women undergoing oocyte retrieval for assisted reproduction
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia vs general analgesia | no estimate extracted | NR | No studies |
Postoperative pain Conscious sedation and analgesia vs general analgesia | no estimate extracted | 1 study · 50 participants | Very low Downgraded: imprecision |
Pregnancy Conscious sedation and analgesia vs general analgesia | OR 1 [0.43, 2.35] | 2 studies · 108 participants | Very low Downgraded: imprecision |
Patient satisfaction (report of 'satisfactory') Conscious sedation and analgesia vs general analgesia | OR 0.66 [0.11, 4.04] | 2 studies · 108 participants | Very low Downgraded: imprecision |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia vs general analgesia | OR 0.46 [0.08, 2.75] | 1 study · 50 participants | Very low Downgraded: imprecision |
Postoperative complications Conscious sedation and analgesia vs general analgesia | OR 0.14 [0.02, 1.22] | 1 study · 58 participants | Very low Downgraded: imprecision |
Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus electro‐acupuncture + PCB
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | no estimate extracted | 4 studies · 781 participants | Low Downgraded: risk of bias |
Postoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | no estimate extracted | NR | No studies |
Pregnancy Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | OR 0.96 [0.72, 1.29] | 4 studies · 783 participants | Low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | no estimate extracted | NR | No studies |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | no estimate extracted | NR | No studies |
Postoperative complications Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs electro‐acupuncture + PCB | no estimate extracted | NR | No studies |
Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus general anaesthesia
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs general anaesthesia | no estimate extracted | NR | No studies |
Postoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs general anaesthesia | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias |
Pregnancy Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs general anaesthesia | OR 0.7 [0.22, 2.26] | 1 study · 51 participants | Very low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs general anaesthesia | no estimate extracted | NR | No studies |
Postoperative complications Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs general anaesthesia | no estimate extracted | NR | No studies |
Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus spinal anaesthesia
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | no estimate extracted | NR | No studies |
Postoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias |
Pregnancy Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | OR 0.93 [0.24, 3.65] | 1 study · 38 participants | Very low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | no estimate extracted | NR | No studies |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | no estimate extracted | NR | No studies |
Postoperative complications Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs spinal anaesthesia | no estimate extracted | NR | No studies |
Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus PCB
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | no estimate extracted | NR | No studies |
Postoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | no estimate extracted | NR | No studies |
Pregnancy Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | OR 0.93 [0.44, 1.96] | 1 study · 150 participants | Low Downgraded: imprecision |
Patient satisfaction Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | OR 1.63 [0.68, 3.89] | 1 study · 150 participants | Low Downgraded: imprecision |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | no estimate extracted | NR | No studies |
Postoperative complications Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs PCB | no estimate extracted | NR | No studies |
Conscious sedation and analgesia (CSA) + paracervical block (PCB) versus CSA
Population: women undergoing oocyte retrieval for assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | no estimate extracted | NR | No studies |
Postoperative pain Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | no estimate extracted | NR | No studies |
Pregnancy Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | OR 0.62 [0.28, 1.36] | 1 study · 100 participants | Very low Downgraded: risk of bias |
Patient satisfaction Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | no estimate extracted | NR | No studies |
Side effects (postoperative vomiting and/or vomiting) Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | OR 0.42 [0.18, 0.97] | 2 studies · 140 participants | Very low Downgraded: risk of bias |
Postoperative complications Conscious sedation and analgesia (CSA) + paracervical block (PCB) vs CSA | no estimate extracted | NR | No studies |
Conscious sedation and analgesia versus other active interventions for women undergoing oocyte retrieval for assisted reproduction
Population: women undergoing oocyte retrieval
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intra‐operative pain Conscious sedation versus conscious sedation + electro‐acupuncture Conscious sedation and analgesia vs other active interventions | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias |
Intra‐operative pain Conscious sedation versus conscious sedation + acupuncture Conscious sedation and analgesia vs other active interventions | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias |
Post‐operative pain Conscious sedation versus conscious sedation + electro‐acupuncture Conscious sedation and analgesia vs other active interventions | no estimate extracted | 1 study · 61 participants | Low Downgraded: risk of bias |
Post‐operative pain Conscious sedation versus conscious sedation + acupuncture (VAS) Conscious sedation and analgesia vs other active interventions | no estimate extracted | 1 study · 61 participants | Low Downgraded: risk of bias |
Post‐operative pain Conscious sedation and analgesia versus general anaesthesia Conscious sedation and analgesia vs other active interventions | no estimate extracted | 1 study · 50 participants | Moderate |
Conscious sedation + paracervical block versus other interventions for women undergoing oocyte retrieval for assisted reproduction.
Population: women undergoing oocyte retrieval
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intra‐operative pain Conscious sedation+paracervical block versus electro‐acupuncture+paracervical block Conscious sedation + paracervical block vs other interventions | no estimate extracted | 4 studies · 781 participants | Low Downgraded: inconsistency |
Post‐operative pain Conscious sedation+paracervical block versus general anaesthesia Conscious sedation + paracervical block vs other interventions | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias |
Post‐operative pain Conscious sedation+paracervical block versus spinal anaesthesia Conscious sedation + paracervical block vs other interventions | no estimate extracted | 1 study · 36 participants | Low Downgraded: risk of bias |
Patient‐controlled sedation compared to physician‐administered sedation for women undergoing oocyte retrieval
Population: women undergoing oocyte retrieval
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean intra‐operative pain score Conscious sedation and analgesia: Patient controlled vs physician controlled Patient‐controlled sedation vs physician‐administered sedation | no estimate extracted | 4 studies · 379 participants | Low |
Mean post‐operative pain score Conscious sedation and analgesia: Patient controlled vs physician controlled Patient‐controlled sedation vs physician‐administered sedation | no estimate extracted | 1 study · 106 participants | Low |