Cochrane · systematic review · CD004147
Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
Amato, L, Minozzi, S, Davoli, M, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 20%High 4 · 80%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAny Psychosocial intervention plus pharm versus pharm standard for treatment of opioid dependence
Population: patients with treatment of opioid dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention in treatment Objective Any Psychosocial intervention plus pharm vs pharm standard | RR 1.02 [0.97, 1.07] | 26 studies · 2582 participants | High |
Opioid abstinence objective Any Psychosocial intervention plus pharm vs pharm standard | RR 1.19 [0.91, 1.56] | 7 studies · 667 participants | High |
Number of participants still in treatment at the end of Any Psychosocial intervention plus pharm vs pharm standard | RR 0.9 [0.77, 1.07] | 3 studies · 250 participants | High |
Number of participants abstinent at the end of Any Psychosocial intervention plus pharm vs pharm standard | RR 1.15 [0.98, 1.36] | 3 studies · 181 participants | High |
Compliance objective Any Psychosocial intervention plus pharm vs pharm standard | no estimate extracted | 3 studies · 685 participants | Moderate Downgraded: risk of bias |
Comparison
Population: patients with treatment of opioid dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention in treatment | RR 1.02 [0.97, 1.07] | 23 studies · 2193 participants | High |
Use of Primary Substance | RR 0.86 [0.65, 1.13] | 8 studies · 681 participants | Moderate |
Number of participants still in treatment at the end of | RR 0.91 [0.77, 1.06] | 4 studies · 289 participants | High |
Number of participants abstinent at the end of | RR 1.15 [1.01, 1.32] | 5 studies · 232 participants | Ungraded |
Compliance | no estimate extracted | 3 studies · 685 participants | Moderate |
Psychiatric symptoms SCL‐90 | no estimate extracted | 4 studies · 323 participants | High |
Depression (BDI) | no estimate extracted | 4 studies · 323 participants | High |