Cochrane · systematic review · CD004128
Hypothermia for neuroprotection in adults after cardiac arrest
Arrich, J, Schütz, N, Oppenauer, J, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 4 · 80%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyEffects of cooling 32 °C to 34 °C on neuroprotection, survival (to discharge or within 6 months) and adverse events for comatose survivors of cardiac arrest
Population: adults after cardiopulmonary resuscitation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Good neurological outcome | RR 1.41 [1.12, 1.76] | 11 studies · 3914 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Survival | RR 1.07 [0.95, 1.2] | 9 studies · 3871 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events – pneumonia | RR 1.09 [1, 1.18] | 4 studies · 3634 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events – hypokalaemia | RR 1.38 [1.03, 1.84] | 2 studies · 975 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse events – arrhythmia | RR 1.4 [1.19, 1.64] | 3 studies · 2163 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological outcome, survival and adverse events: conventional cooling compared with no cooling and 36°C for neuroprotection and survival in adults after cardiopulmonary resuscitation
Population: adults after cardiopulmonary resuscitation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Good neurological outcome Neurological outcome, survival and adverse events: conventional cooling vs no cooling and 36°C | RR 1.94 [1.18, 3.21] | 4 studies · 437 participants | Moderate |
Survival Neurological outcome, survival and adverse events: conventional cooling vs no cooling and 36°C | RR 1.35 [1.1, 1.65] | 3 studies · 383 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Adverse events ‐ pneumonia Neurological outcome, survival and adverse events: conventional cooling vs no cooling and 36°C | RR 1.15 [1.02, 1.3] | 2 studies · 1205 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Adverse events ‐ hypokalaemia Neurological outcome, survival and adverse events: conventional cooling vs no cooling and 36°C | RR 1.38 [1.03, 1.84] | 2 studies · 975 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Neurological outcome and survival: conventional cooling compared to no cooling for neuroprotection and survival in adults after cardiopulmonary resuscitation
Population: comatose patients after cardiopulmonary resuscitation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Good neurological outcome ‐ Conventional cooling without extracorporal methods (IPD, best ever reached CPC of 1 or 2 during hospital stay) CPC1 Neurological outcome and survival: conventional cooling vs no cooling | RR 1.55 [1.22, 1.96] | 3 studies · 383 participants | Moderate |
Survival ‐ Conventional cooling without extracorporal methods (IPD, survival to discharge) (Copy) discharge information and telephone Neurological outcome and survival: conventional cooling vs no cooling | RR 1.35 [1.1, 1.65] | 3 studies · 383 participants | Moderate |