Cochrane · systematic review · CD004089

Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures

Bampoe, S, Odor, PM, Dushianthan, A, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Anaesthesia2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Buffered versus non‐buffered crystalloid intravenous fluid for adults undergoing any form of surgery

Population: adults receiving intravenous fluids whilst undergoing any form of surgery

CD004089.PUB3 (current) · 4 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality (in‐hospital death and 30‐day mortality) Buffered vs non‐buffered crystalloid intravenous fluid	OR 1.85 [0.37, 9.33]	3 studies · 267 participants	Low Downgraded: risk of bias, imprecision
Organ system failure ‐ renal insufficiency requiring support Buffered vs non‐buffered crystalloid intravenous fluid	OR 0.82 [0.34, 1.98]	4 studies · 267 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Plasma pH ‐ postoperative pH Buffered vs non‐buffered crystalloid intravenous fluid	no estimate extracted	12 studies · 720 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency
Serum chloride (mmol/L) ‐ postoperative chloride Buffered vs non‐buffered crystalloid intravenous fluid	no estimate extracted	10 studies · 530 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency

Buffered versus non‐buffered fluid administration in perioperative patients

Population: Perioperative patients

CD004089.PUB2 · 4 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality Buffered vs non‐buffered fluid administration	OR 1.85 [0.37, 9.33]	3 studies · 267 participants	Moderate
Organ system failure ‐ Renal insufficiency leading to replacement therapy Buffered vs non‐buffered fluid administration	OR 0.61 [0.23, 1.63]	3 studies · 207 participants	Low
Postoperative pH Buffered vs non‐buffered fluid administration	no estimate extracted	8 studies · 450 participants	Moderate
Postoperative chloride mmol/L Buffered vs non‐buffered fluid administration	no estimate extracted	9 studies · 480 participants	Moderate