Cochrane · systematic review · CD003711
Herbal medicines for viral myocarditis
Liu Zhao Lan, Liu Zhi Jun, Liu Jian Ping, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 41.7%Low 3 · 25%Moderate 4 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHerbal medicines versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients died of cardiac failure: Astragaloside injection versus supportive therapy Herbal medicines vs supportive therapy | RR 1.22 [0.34, 4.38] | 1 study · 164 participants | Very low Downgraded: risk of bias, imprecision |
Number of patients with premature beat: Xinshu capsule versus supportive therapy Herbal medicines vs supportive therapy | RR 0.84 [0.56, 0.99] | 1 study · 120 participants | Very low Downgraded: risk of bias, imprecision |
Herbal medicines plus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with premature beat: Qi Lu decoction plus supportive therapy versus supportive therapy alone | RR 0.71 [0.5, 1] | 1 study · 111 participants | Low Downgraded: risk of bias |
Number of patients with premature beat: Shortscape Fleabane injection plus supportive therapy versus supportive therapy alone | RR 0.9 [0.67, 1.2] | 1 study · 83 participants | Low Downgraded: risk of bias |
Number of patients with premature beat: Astragaloside injection plus supportive therapy versus supportive therapy alone | RR 1.09 [0.69, 1.71] | 1 study · 93 participants | Low Downgraded: risk of bias |
Number of patients with premature beat: Compound Qiangqi pill plus supportive therapy versus supportive therapy alone | RR 0.8 [0.36, 1.77] | 1 study · 14 participants | Moderate Downgraded: imprecision |
Number of patients with premature beat: Shengmai decoction plus supportive therapy versus supportive therapy alone | RR 1 [0.52, 1.94] | 1 study · 14 participants | Moderate Downgraded: imprecision |
Number of patients with premature beat: Danhong injection plus supportive therapy versus supportive therapy alone | RR 0.48 [0.24, 0.96] | 1 study · 61 participants | Moderate Downgraded: risk of bias |
Number of patients with arrhythmia: Astragaloside injection plus supportive therapy versus supportive therapy alone | RR 0.47 [0.14, 1.18] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
Number of patients with arrhythmia: Garlicin injection plus supportive therapy versus supportive therapy alone | RR 0.22 [0.05, 0.86] | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision |
Number of patients with arrhythmia: Danhong injection plus supportive therapy versus supportive therapy alone | RR 0.71 [0.45, 1.04] | 1 study · 224 participants | Moderate Downgraded: risk of bias |
Herbal medicines plus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with premature beat: Astragaloside injection plus supportive therapy versus Acyclovir plus supportive therapy | RR 0.31 [0.09, 0.83] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Herbal medicines versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients died of cardiac failure ‐ Astragaloside injection versus support therapy Herbal medicines vs supportive therapy | RR 1.22 [0.34, 4.38] | 1 study · 164 participants | Very low Downgraded: risk of bias, imprecision |
Number of patients with premature beat ‐ Xinshu Capsule versus supportive therapy Herbal medicines vs supportive therapy | RR 0.84 [0.56, 0.99] | 1 study · 120 participants | Very low Downgraded: risk of bias, imprecision |
Herbal medicines plus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with premature beat ‐ Qi Lu Decoction plus support therapy versus support therapy | RR 0.71 [0.5, 1] | 1 study · 111 participants | Low Downgraded: risk of bias |
Number of patients with premature beat ‐ Shortscape fleabane injection plus support therapy versus support therapy | RR 0.9 [0.67, 1.2] | 1 study · 83 participants | Low Downgraded: risk of bias |
Number of patients with premature beat ‐ Astragaloside injection plus support therapy versus support therapy | RR 1.09 [0.69, 1.71] | 1 study · 93 participants | Low Downgraded: risk of bias |
Number of patients with premature beat ‐ Compound Qiangqi pill plus supportive therapy versus supportive therapy | RR 0.8 [0.36, 1.77] | 1 study · 14 participants | Moderate Downgraded: imprecision |
Number of patients with premature beat ‐ Shengmai decoction plus supportive therapy versus supportive therapy | RR 1 [0.52, 1.94] | 1 study · 14 participants | Moderate Downgraded: imprecision |
Number of patients with premature beat ‐ Danhong injection plus support therapy versus support therapy | RR 0.48 [0.24, 0.96] | 1 study · 61 participants | Moderate Downgraded: risk of bias |
number of patients with arrhythmia ‐ Astragaloside injection plus support therapy versus support therapy | RR 0.47 [0.14, 1.18] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
number of patients with arrhythmia ‐ Garlincin injection plus support therapy versus support therapy | RR 0.22 [0.05, 0.86] | 1 study · 44 participants | Very low Downgraded: risk of bias, imprecision |
number of patients with arrhythmia ‐ Danhong injection plus support therapy versus support therapy | RR 0.71 [0.45, 1.04] | 1 study · 224 participants | Moderate Downgraded: risk of bias |
Herbal medicines plus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
number of patients with premature beat ‐ Astragaloside injection plus support therapy versus Acyclovir plus support therapy | RR 0.31 [0.09, 0.83] | 1 study · 73 participants | Very low Downgraded: risk of bias, imprecision |
Main findings of Herbal medicines versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients without symptom improvement ‐ Shenmai injection versus support therapy Main findings of Herbal medicines vs supportive therapy | RR 0.32 [0.14, 0.75] | 1 study · 127 participants | Very low Downgraded: risk of bias, imprecision |
Number of patients without symptom improvement ‐ Xinshu Capsule versus supportive therapy Main findings of Herbal medicines vs supportive therapy | RR 0.14 [0.04, 0.45] | 1 study · 120 participants | Low Downgraded: risk of bias |
Number of patients with premature beat ‐ Xinshu Capsule versus supportive therapy Main findings of Herbal medicines vs supportive therapy | OR 0.21 [0.06, 0.79] | 1 study · 120 participants | Very low Downgraded: risk of bias, imprecision |
Main findings of Herbal medicines plus supportive therapy versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients without symptom improvement ‐ Astragaloside injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | RR 0.53 [0.34, 0.85] | 4 studies · 300 participants | Low Downgraded: risk of bias |
Number of patients without symptom improvement ‐ Qi Lu Decoction plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | RR 0.16 [0.04, 0.69] | 1 study · 168 participants | Very low Downgraded: risk of bias, imprecision |
Abnormal electrocardiogram ‐ Qingxinhuoming Decoction plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | RR 0.32 [0.13, 0.79] | 1 study · 78 participants | Low Downgraded: risk of bias, imprecision |
Abnormal electrocardiogram ‐ Shengyangyixin Decoction plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | RR 0.56 [0.35, 0.9] | 1 study · 76 participants | Low Downgraded: risk of bias |
Abnormal electrocardiogram ‐ Astragaloside injection plus supportive therapy versus supportive therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | RR 0.25 [0.08, 0.8] | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Main findings of Herbal medicines plus supportive therapy versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Myocardial enzyme CPK levels (U/L) ‐ Astragaloside injection plus support therapy versus support therapy U/L Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 2 studies · 120 participants | Very low Downgraded: risk of bias, imprecision |
Myocardial enzyme CPK levels (U/L) ‐ Shortscape fleabane injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 83 participants | Low Downgraded: risk of bias, imprecision |
Myocardial enzyme LDH levels (U/L) ‐ Shengyangyixin Decoction plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 76 participants | Low Downgraded: risk of bias |
Myocardial enzyme LDH levels (U/L) ‐ Astragaloside injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 2 studies · 120 participants | Very low Downgraded: risk of bias, imprecision |
Myocardial enzyme LDH levels (U/L) ‐ Shortscape fleabane injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 83 participants | Very low Downgraded: risk of bias, imprecision |
Symptom scores ‐ Shortscape fleabane injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 83 participants | Low Downgraded: risk of bias |
Cardiac function LVET (%) ‐ Astragaloside injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 98 participants | Low Downgraded: risk of bias, imprecision |
Main findings of Herbal medicines plus supportive therapy versus supportive therapy for viral myocarditis
Population: patients with viral myocarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cardiac function LVET (%) ‐ Astragalus membranaceus plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias |
Myocardial enzyme CK‐MB levels (U/L) ‐ Astragalus membranaceus plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias |
Myocardial enzyme CK‐MB levels (U/L) ‐ Shengyangyixin Decoction plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 76 participants | Low Downgraded: risk of bias |
Myocardial enzyme CK‐MB levels (U/L) ‐ Shortscape fleabane injection plus support therapy versus support therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 83 participants | Low Downgraded: risk of bias, imprecision |
scores of quality of life measured by SF‐36 ‐ Compound Qiangqi pill plus supportive therapy versus supportive therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 80 participants | Moderate Downgraded: imprecision |
scores of quality of life measured by SF‐36 ‐ Shengmai decoction plus supportive therapy versus supportive therapy Main findings of Herbal medicines plus supportive therapy vs supportive therapy | no estimate extracted | 1 study · 80 participants | High |