Cochrane · systematic review · CD003664
Infant formulas containing hydrolysed protein for prevention of allergic disease
Osborn, DA, Sinn, JKH, Jones, LJ · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 19 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyEarly short‐term feeding: hydrolysed formula versus human milk feeding ‐ low‐risk infants for prevention of allergic disease
Population: infants not selected for allergic disease risk.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 1.43 [0.38, 5.37] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Asthma ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.48 [0.05, 4.41] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.48 [0.05, 4.41] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 1.43 [0.38, 5.37] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ infancy (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.87 [0.52, 1.46] | 1 study · 3559 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 7.11 [0.35, 143.84] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Early short‐term feeding: hydrolysed formula versus cow's milk formula ‐ low‐risk infants for prevention of allergic disease and food allergy
Population: infants not selected for allergic disease risk.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 1.37 [0.33, 5.71] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Asthma ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 3.08 [0.13, 73.26] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 0.34 [0.04, 3.15] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 1.37 [0.33, 5.71] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ infancy (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 0.62 [0.38, 1] | 1 study · 3473 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 5.13 [0.25, 103.43] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Prolonged feeding: hydrolysed formula versus cow's milk formula for prevention of allergic disease
Population: infants.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.88 [0.76, 1.01] | 8 studies · 2852 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
All allergic disease ‐ Childhood (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.85 [0.69, 1.05] | 2 studies · 950 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Asthma ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.57 [0.31, 1.04] | 4 studies · 318 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.93 [0.79, 1.09] | 9 studies · 2896 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Rhinitis ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.52 [0.14, 1.85] | 3 studies · 256 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 1.42 [0.87, 2.33] | 2 studies · 479 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ Infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 2.31 [0.24, 21.97] | 1 study · 338 participants | Very low Downgraded: imprecision |
Early short‐term feeding: hydrolysed formula versus human milk feeding ‐ low‐risk infants for prevention of allergic disease and food allergy
Population: infants not selected for allergy risk
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 1.43 [0.38, 5.37] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Asthma ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.48 [0.05, 4.41] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.48 [0.05, 4.41] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 1.43 [0.38, 5.37] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ infancy (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 0.87 [0.52, 1.46] | 1 study · 3559 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants | RR 7.11 [0.35, 143.84] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Early short‐term feeding: hydrolysed formula versus cow's milk formula ‐ low‐risk infants for prevention of allergic disease and food allergy
Population: infants not selected for allergy risk
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 1.37 [0.33, 5.71] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Asthma ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 3.08 [0.13, 73.26] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 0.34 [0.04, 3.15] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 1.37 [0.33, 5.71] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ infancy (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 0.62 [0.38, 1] | 1 study · 3473 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ childhood (incidence) Early short‐term feeding: hydrolysed formula vs cow's milk formula ‐ low‐risk infants | RR 5.13 [0.25, 103.43] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Prolonged feeding: hydrolysed formula versus cow's milk formula for prevention of allergic disease and food allergy
Population: infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any allergy ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.82 [0.72, 0.95] | 8 studies · 2852 participants | Very low Downgraded: risk of bias |
Any allergy ‐ childhood (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.85 [0.69, 1.05] | 2 studies · 950 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Asthma ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.57 [0.31, 1.04] | 4 studies · 318 participants | Very low Downgraded: risk of bias, imprecision |
Eczema ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.86 [0.73, 1.01] | 9 studies · 2896 participants | Very low Downgraded: risk of bias, imprecision |
Rhinitis ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.52 [0.14, 1.85] | 3 studies · 256 participants | Very low Downgraded: risk of bias, imprecision |
Food allergy ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.95 [0.58, 1.54] | 2 studies · 479 participants | Very low Downgraded: risk of bias, imprecision |
Cow's milk allergy ‐ infancy (incidence) Prolonged feeding: hydrolysed formula vs cow's milk formula | RR 0.38 [0.16, 0.86] | 2 studies · 405 participants | Very low Downgraded: risk of bias, imprecision |