Cochrane · systematic review · CD003416
Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection
Kamath, MS, Mascarenhas, M, Kirubakaran, R, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 75%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyRepeated single embryo transfer (mixed policies) versus multiple embryo transfer in a single cycle of IVF or ICSI
Population: transfer following in vitro fertilisation or intracytoplasmic sperm injection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cumulative live birth Repeated single embryo transfer (mixed policies) vs multiple embryo transfer | RR 0.95 [0.82, 1.1] | 4 studies · 985 participants | Low Downgraded: risk of bias |
Multiple pregnancy Repeated single embryo transfer (mixed policies) vs multiple embryo transfer | odds ratio 0.13 [0.08, 0.21] | 4 studies · 985 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate Repeated single embryo transfer (mixed policies) vs multiple embryo transfer | RR 0.95 [0.84, 1.08] | 3 studies · 943 participants | Low Downgraded: risk of bias |
Miscarriage rate Repeated single embryo transfer (mixed policies) vs multiple embryo transfer | odds ratio 2.14 [0.93, 4.95] | 2 studies · 282 participants | Low Downgraded: risk of bias, imprecision |
Single compared to multiple embryo transfer in a single cycle following IVF or ICSI
Population: transfer following in vitro fertilisation or intracytoplasmic sperm injection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Single vs multiple embryo transfer | RR 0.67 [0.59, 0.75] | 12 studies · 1904 participants | Low Downgraded: risk of bias |
Multiple pregnancy Single vs multiple embryo transfer | odds ratio 0.16 [0.12, 0.22] | 13 studies · 1952 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy Single vs multiple embryo transfer | RR 0.7 [0.64, 0.77] | 10 studies · 1860 participants | Low Downgraded: risk of bias |
Miscarriage rate Single vs multiple embryo transfer | odds ratio 0.96 [0.66, 1.42] | 7 studies · 1560 participants | Low Downgraded: risk of bias, imprecision |
Repeated single embryo transfer compared to double embryo transfer
Population: women having embryo transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cumulative live birth Repeated single embryo transfer versus double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.82 [0.62, 1.09] | 811 participants | Low Downgraded: risk of bias |
Cumulative live birth ‐ Single embryo transfer plus one cycle of frozen embryo transfer versus one cycle of double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.83 [0.61, 1.12] | 703 participants | Low Downgraded: risk of bias |
Cumulative live birth ‐ Two cycles of single embryo transfer SET (x2) versus one cycle of double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.79 [0.36, 1.72] | 108 participants | Very low Downgraded: risk of bias |
Multiple pregnancy Repeated single embryo transfer versus double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.03 [0.01, 0.13] | 811 participants | Low Downgraded: risk of bias |
Multiple pregnancy Single embryo transfer plus one cycle of frozen embryo transfer versus one cycle of double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.03 [0.01, 0.14] | 703 participants | Low Downgraded: risk of bias |
Multiple pregnancy Two cycles of single embryo transfer SET (x2) versus one cycle of double embryo transfer Repeated single embryo transfer vs double embryo transfer | OR 0.07 [0, 1.25] | 108 participants | Very low Downgraded: risk of bias |
Single embryo transfer compared to double embryo transfer (in a single cycle)
Population: women having embryo transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Multiple pregnancy Single embryo transfer vs double embryo transfer (in a single cycle) | OR 0.12 [0.07, 0.2] | 1612 participants | High |
Live birth Single embryo transfer vs double embryo transfer (in a single cycle) | OR 0.48 [0.39, 0.6] | 1564 participants | High |