Cochrane · systematic review · CD003214

Inhaled bronchodilators for the prevention and treatment of chronic lung disease in preterm infants

Ng, G, Bruschettini, M, Ibrahim, J, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 25%Ungraded 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table ‐ Salbutamol compared to placebo in the prophylaxis of chronic lung disease

Population: preterm infants (< 37 weeks GA) at risk of chronic lung disease

CD003214.PUB4 (current) · 4 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality within the trial period Summary of findings table ‐ Salbutamol vs placebo	RR 1.08 [0.5, 2.31]	1 study · 173 participants	Low Downgraded: imprecision
Chronic lung disease at 28 days Summary of findings table ‐ Salbutamol vs placebo	RR 1.03 [0.78, 1.37]	1 study · 173 participants	Low Downgraded: imprecision
Adverse effects of bronchodilators, including hypokalaemia, tachycardia, cardiac arrhythmia, tremor, hypertension and hyperglycaemia ‐ not reported Summary of findings table ‐ Salbutamol vs placebo	no estimate extracted	NR	No studies
Pneumothorax Summary of findings table ‐ Salbutamol vs placebo	no estimate extracted	1 study · 173 participants	Very low Downgraded: imprecision

Comparison

Population: preterm infants at risk of having CLD

CD003214.PUB3 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality	RR 1.08 [0.5, 2.31]	1 study · 173 participants	Low
CLD at 28 days	1.03 [0.78, 1.37]	1 study · 173 participants	Moderate

Comparison

Population: preterm infants at risk of developing CLD

CD003214.PUB3 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality	RR 3 [0.33, 26.99]	1 study · 52 participants	Very low
CLD at 28 days	RR 0.18 [0.04, 0.74]	1 study · 52 participants	Very low