Cochrane · systematic review · CD003211
Feed thickener for infants up to six months of age with gastro‐oesophageal reflux
Kwok, TC, Ojha, S, Dorling, J · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Feed thickener compared to control for infants up to 6 months of age with gastro‐oesophageal reflux
Population: Formula‐fed healthy term infants up to 6 months of age with gastro‐oesophageal reflux
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of episodes of regurgitation or vomiting per day Feed thickener vs control | no estimate extracted | 6 studies · 442 participants | Moderate Downgraded: risk of bias |
Proportion of infants without regurgitation or vomiting at the end of intervention period (asymptomatic infants) Feed thickener vs control | RR 2.5 [1.38, 4.51] | 2 studies · 186 participants | Low Downgraded: risk of bias, imprecision |
Reflux index (percentage of time pH < 4) Feed thickener vs control | no estimate extracted | 2 studies · 116 participants | Low Downgraded: risk of bias, imprecision |
Number of reflux episodes lasting > 5 minutes Feed thickener vs control | no estimate extracted | 2 studies · 116 participants | Low Downgraded: risk of bias, imprecision |
Duration of longest reflux episode Feed thickener vs control | no estimate extracted | 2 studies · 116 participants | Low Downgraded: risk of bias, imprecision |
Diarrhoea Feed thickener vs control | no estimate extracted | 6 studies · 511 participants | Low Downgraded: risk of bias, publication bias |