Cochrane · systematic review · CD003179
Adrenaline and vasopressin for cardiac arrest
Finn, J, Jacobs, I, Williams, TA, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 9 · 56.3%Low 4 · 25%Moderate 3 · 18.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Standard‐dose adrenaline (SDA) compared to placebo for cardiac arrest
Population: people suffering cardiac arrest
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Standard‐dose adrenaline (SDA) vs placebo | RR 1.44 [1.11, 1.86] | 2 studies · 8538 participants | Moderate Downgraded: risk of bias, imprecision |
Survival to hospital admission Standard‐dose adrenaline (SDA) vs placebo | RR 2.51 [1.67, 3.76] | 2 studies · 8489 participants | Moderate Downgraded: risk of bias, imprecision |
Favourable neurological outcomes Standard‐dose adrenaline (SDA) vs placebo | RR 1.21 [0.9, 1.62] | 2 studies · 8535 participants | Low Downgraded: risk of bias, imprecision |
Return of spontaneous circulation Standard‐dose adrenaline (SDA) vs placebo | RR 2.86 [2.21, 3.71] | 3 studies · 8663 participants | Moderate Downgraded: risk of bias, imprecision |
Standard‐dose adrenaline (SDA) compared to high‐dose adrenaline (HDA) for cardiac arrest
Population: people suffering cardiac arrest
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA) | RR 1.1 [0.75, 1.62] | 10 studies · 6274 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Survival to hospital admission Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA) | RR 1.13 [1.03, 1.24] | 5 studies · 5764 participants | Very low Downgraded: risk of bias, inconsistency |
Favourable neurological outcomes Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA) | RR 0.91 [0.65, 1.26] | 4 studies · 5803 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Return of spontaneous circulation Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA) | RR 1.15 [1.02, 1.29] | 13 studies · 7014 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Standard‐dose adrenaline (SDA) compared to vasopressin for cardiac arrest
Population: people suffering cardiac arrest
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Standard‐dose adrenaline (SDA) vs vasopressin | RR 1.25 | 6 studies · 2511 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Survival to hospital admission Standard‐dose adrenaline (SDA) vs vasopressin | RR 1.27 [1.04, 1.54] | 3 studies · 1953 participants | Low Downgraded: inconsistency |
Favourable neurological outcomes Standard‐dose adrenaline (SDA) vs vasopressin | RR 0.82 [0.54, 1.25] | 4 studies · 2406 participants | Very low Downgraded: imprecision, inconsistency |
Return of spontaneous circulation Standard‐dose adrenaline (SDA) vs vasopressin | RR 1.1 [0.9, 1.33] | 6 studies · 2531 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Standard‐dose adrenaline (SDA) compared to SDA plus vasopressin for cardiac arrest
Population: people suffering cardiac arrest
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival to hospital discharge Standard‐dose adrenaline (SDA) vs SDA plus vasopressin | RR 0.76 [0.47, 1.22] | 3 studies · 3242 participants | Very low Downgraded: imprecision, inconsistency |
Survival to hospital admission Standard‐dose adrenaline (SDA) vs SDA plus vasopressin | RR 0.95 [0.83, 1.08] | 3 studies · 3249 participants | Low Downgraded: imprecision |
Favourable neurological outcomes Standard‐dose adrenaline (SDA) vs SDA plus vasopressin | RR 0.65 [0.33, 1.31] | 1 study · 2887 participants | Very low Downgraded: imprecision, inconsistency |
Return of spontaneous circulation Standard‐dose adrenaline (SDA) vs SDA plus vasopressin | RR 0.97 [0.87, 1.08] | 3 studies · 3249 participants | Low Downgraded: imprecision |