Cochrane · systematic review · CD003115
Oral or transdermal opioids for osteoarthritis of the knee or hip
da Costa, BR, Nüesch, E, Kasteler, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyOral or transdermal opioids compared with placebo for osteoarthritis of the knee or hip
Population: participants with osteoarthritis of the knee or hip
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity Various pain scales. (median Oral or transdermal opioids vs placebo | no estimate extracted | 22 studies · 8275 participants | High |
Function Various validated function scales. (median Oral or transdermal opioids vs placebo | no estimate extracted | 12 studies · 3553 participants | High |
Number of participants experiencing any adverse event (median Oral or transdermal opioids vs placebo | RR 1.49 [1.35, 1.63] | 9 studies · 4898 participants | Moderate Downgraded: risk of bias |
Number of participants who withdrew because of adverse events (median Oral or transdermal opioids vs placebo | RR 3.76 [2.93, 4.82] | 19 studies · 7712 participants | High |
Number of participants experiencing any serious adverse event (median Oral or transdermal opioids vs placebo | RR 3.35 [0.83, 13.56] | 3 studies · 681 participants | Low Downgraded: risk of bias |
Withdrawal symptoms (median Oral or transdermal opioids vs placebo | OR 2.67 [2.02, 3.77] | 3 studies · 1151 participants | Moderate Downgraded: risk of bias |
Comparison
Population: Patients with osteoarthritis of the knee or hip
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity Various pain scales. (median | no estimate extracted | 10 studies · 2268 participants | High |
Function Various validated function scales. (median | no estimate extracted | 7 studies · 1794 participants | High |
Number of patients experiencing any adverse event (median | RR 1.55 [1.41, 1.7] | 4 studies · 1080 participants | Moderate Downgraded: risk of bias |
Number of patients who withdrew because of adverse events (median | RR 4.05 [3.06, 5.38] | 10 studies · 2403 participants | High |
Number of patients experiencing any serious adverse event (median | RR 3.35 [0.83, 13.56] | 3 studies · 681 participants | Low Downgraded: risk of bias |
Withdrawal symptoms Short Opiate Withdrawal Scale. ( | SMD 0.6 [0.42, 0.79] | 1 study · 499 participants | Low Downgraded: risk of bias |