Cochrane · systematic review · CD002811
Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome
D'Angelo, A, Amso, NN, Hassan, R · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
25
current version
GRADE rated
14
No studies
11
Included studies
NR
No studies 11 · 44%Ungraded 0 · 0%Very low 9 · 36%Low 5 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCoasting versus no coasting for prevention of ovarian hyperstimulation syndrome
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs no coasting | OR 0.11 [0.05, 0.24] | 2 studies · 207 participants | Low Downgraded: risk of bias, imprecision |
Live birth Coasting vs no coasting | OR 0.48 [0.14, 1.62] | 1 study · 68 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy Coasting vs no coasting | OR 0.82 [0.46, 1.44] | 2 studies · 207 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy Coasting vs no coasting | OR 0.31 [0.12, 0.81] | 1 study · 139 participants | Low Downgraded: risk of bias, imprecision |
Miscarriage Coasting vs no coasting | OR 0.85 [0.25, 2.86] | 2 studies · 207 participants | Very low Downgraded: risk of bias, imprecision |
Coasting versus early unilateral follicular aspiration for preventing ovarian hyperstimulation syndrome
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs early unilateral follicular aspiration | OR 0.98 [0.34, 2.85] | 2 studies · 83 participants | Very low Downgraded: risk of bias, imprecision |
Live birth Coasting vs early unilateral follicular aspiration | no estimate extracted | NR | No studies |
Clinical Pregnancy Coasting vs early unilateral follicular aspiration | OR 0.67 [0.25, 1.79] | 2 studies · 83 participants | Very low Downgraded: risk of bias, imprecision |
Multiple pregnancy Coasting vs early unilateral follicular aspiration | no estimate extracted | NR | No studies |
Miscarriage Coasting vs early unilateral follicular aspiration | no estimate extracted | NR | No studies |
Coasting versus gonadotrophin‐releasing hormone antagonist for preventing ovarian hyperstimulation syndrome
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs gonadotrophin‐releasing hormone antagonist | no estimate extracted | 1 study · 190 participants | Very low Downgraded: risk of bias |
Live birth Coasting vs gonadotrophin‐releasing hormone antagonist | no estimate extracted | NR | No studies |
Clinical Pregnancy Coasting vs gonadotrophin‐releasing hormone antagonist | OR 0.74 [0.42, 1.31] | 1 study · 190 participants | Low Downgraded: risk of bias |
Multiple pregnancy Coasting vs gonadotrophin‐releasing hormone antagonist | OR 0.84 [0.39, 1.8] | 1 study · 98 participants | Very low Downgraded: risk of bias |
Miscarriage Coasting vs gonadotrophin‐releasing hormone antagonist | no estimate extracted | NR | No studies |
Coasting versus follicle stimulating hormone administration at time of hCG for preventing ovarian hyperstimulation syndrome
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs follicle stimulating hormone administration at time of hCG | OR 43.74 [2.54, 754.58] | 1 study · 102 participants | Very low Downgraded: risk of bias, imprecision |
Live birth Coasting vs follicle stimulating hormone administration at time of hCG | no estimate extracted | NR | No studies |
Clinical Pregnancy Coasting vs follicle stimulating hormone administration at time of hCG | OR 0.92 [0.43, 2.01] | 1 study · 102 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy Coasting vs follicle stimulating hormone administration at time of hCG | no estimate extracted | NR | No studies |
Miscarriage Coasting vs follicle stimulating hormone administration at time of hCG | no estimate extracted | NR | No studies |
Coasting compared to cabergoline for preventing ovarian hyperstimulation syndrome
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs cabergoline | OR 1.98 [0.69, 5.68] | 2 studies · 120 participants | Very low Downgraded: risk of bias, imprecision |
Live birth Coasting vs cabergoline | no estimate extracted | NR | No studies |
Clinical pregnancy rate Coasting vs cabergoline | OR 0.38 [0.16, 0.88] | 2 studies · 120 participants | Very low Downgraded: risk of bias, imprecision |
Multiple pregnancy Coasting vs cabergoline | no estimate extracted | NR | No studies |
Miscarriage Coasting vs cabergoline | no estimate extracted | NR | No studies |
Coasting versus no coasting for preventing ovarian hyperstimulation syndrome
Population: patients with preventing ovarian hyperstimulation syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs no coasting | OR 0.17 [0.03, 0.88] | 1 study · 68 participants | Very low |
Live birth Coasting vs no coasting | OR 0.48 [0.14, 1.62] | 1 study · 68 participants | Very low |
Clinical Pregnancy Coasting vs no coasting | OR 0.56 [0.2, 1.63] | 1 study · 68 participants | Very low |
Number of oocytes retrieved Coasting vs no coasting | no estimate extracted | 1 study · 68 participants | Very low |
Miscarriage Coasting vs no coasting | OR 0.65 [0.1, 4.13] | 1 study · 68 participants | Very low |
Coasting versus no coasting for preventing ovarian hyperstimulation syndrome
Population: patients with preventing ovarian hyperstimulation syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs no coasting | OR 0.17 [0.03, 0.88] | 1 study · 68 participants | Very low |
Live birth Coasting vs no coasting | OR 0.48 [0.14, 1.62] | 1 study · 68 participants | Very low |
Clinical Pregnancy Coasting vs no coasting | OR 0.56 [0.2, 1.63] | 1 study · 68 participants | Very low |
Number of oocytes retrieved Coasting vs no coasting | no estimate extracted | 1 study · 68 participants | Very low |
Miscarriage Coasting vs no coasting | OR 0.65 [0.1, 4.13] | 1 study · 68 participants | Very low |
Coasting versus no coasting for preventing ovarian hyperstimulation syndrome
Population: patients with preventing ovarian hyperstimulation syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
OHSS Coasting vs no coasting | OR 0.17 [0.03, 0.88] | 1 study · 68 participants | Very low |
Live birth Coasting vs no coasting | OR 0.48 [0.14, 1.62] | 1 study · 68 participants | Very low |
Clinical Pregnancy Coasting vs no coasting | OR 0.56 [0.2, 1.63] | 1 study · 68 participants | Very low |
Number of oocytes retrieved Coasting vs no coasting | no estimate extracted | 1 study · 68 participants | Very low |
Miscarriage Coasting vs no coasting | OR 0.65 [0.1, 4.13] | 1 study · 68 participants | Very low |