Cochrane · systematic review · CD002787
Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
Gebistorf, F, Karam, O, Wetterslev, J, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyINO compared with control group for acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) in children and adults
Population: critically ill participants with ALI and ARDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality INO vs control group | RR 1.04 [0.9, 1.19] | 13 studies · 1243 participants | Moderate |
Overall mortality at 28 days INO vs control group | RR 1.08 [0.92, 1.27] | 9 studies · 1105 participants | Moderate Downgraded: risk of bias |
Mortality in paediatric population (subgroup) INO vs control group | RR 0.78 [0.51, 1.18] | 185 participants | Moderate Downgraded: risk of bias |
PaO2/FiO2 up to 24 hours INO vs control group | MD 15.91 [8.25, 23.56] | 11 studies · 614 participants | Moderate Downgraded: risk of bias |
Oxygenation index, 24 hours INO vs control group | no estimate extracted | 5 studies · 368 participants | Moderate Downgraded: risk of bias |
Ventilation‐free days, up to 30 days INO vs control group | no estimate extracted | 5 studies · 804 participants | High |
Renal impairment INO vs control group | RR 1.59 [1.17, 2.16] | 4 studies · 945 participants | High |
INO compared to control group for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults
Population: patients with ALI and ARDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Longest INO vs control group | RR 1.06 [0.93, 1.22] | 14 studies · 1250 participants | Low |
Mortality: Paediatric trials, INO vs. control INO vs control group | RR 0.97 [0.67, 1.38] | 3 studies · 162 participants | Low Downgraded: risk of bias |
Renal impairment: INO vs. control INO vs control group | RR 1.59 [1.17, 2.16] | 4 studies · 945 participants | Low |
PaO2/FiO2 up to 24 hours, INO vs. control INO vs control group | no estimate extracted | 11 studies · 614 participants | Low |
Oxygenation index 24 hours, INO vs. control INO vs control group | no estimate extracted | 4 studies · 317 participants | Moderate |
Circulatory failure & Shock: INO vs. control INO vs control group | RR 1.49 [0.9, 2.47] | 2 studies · 288 participants | Moderate |
Bleeding events: INO vs. control INO vs control group | RR 0.88 [0.43, 1.79] | 5 studies · 614 participants | Low |