Cochrane · systematic review · CD002783
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
Broderick, C, Watson, L, Armon, MP · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyTreatment with any thrombolysis strategy for acute deep vein thrombosis
Population: patients diagnosed with acute DVT
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clot lysis (intermediate, 6 months to under 5 years after treatment) | RR 2.42 [1.42, 4.12] | 7 studies · 654 participants | Moderate |
Bleeding (early, up to 1 month after treatment) | RR 2.45 [1.58, 3.78] | 19 studies · 1943 participants | Moderate |
Post‐thrombotic syndrome (intermediate, 6 months to under 5 years after treatment) | RR 0.78 [0.66, 0.93] | 6 studies · 1393 participants | Moderate |
Post‐thrombotic syndrome (late, 5 years | RR 0.56 [0.43, 0.73] | 2 studies · 211 participants | Moderate |
Treatment with any thrombolysis for acute deep vein thrombosis
Population: patients diagnosed with acute DVT
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clot lysis (intermediate, 6 months to under 5 years after treatment) | RR 2.44 [1.4, 4.27] | 7 studies · 630 participants | Moderate |
Bleeding (early, up to 1 month after treatment) | RR 2.23 [1.41, 3.52] | 17 studies · 1103 participants | Moderate |
Post‐thrombotic syndrome (intermediate, 6 months to under 5 years after treatment) | RR 0.66 [0.53, 0.81] | 3 studies · 306 participants | Moderate |
Post‐thrombotic syndrome (late, 5 year | RR 0.58 [0.45, 0.77] | 2 studies · 211 participants | Moderate |
Treatment with catheter directed thrombolysis for acute deep venous thrombosis
Population: patients diagnosed with acute deep vein thrombosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clot lysis (intermediate, 6 months to under 5 years after treatment) | RR 2.52 [0.52, 12.17] | 2 studies · 224 participants | Moderate |
Bleeding (early, up to 1 month after treatment) | RR 7.69 [0.4, 146.9] | 2 studies · 224 participants | Moderate |
Post‐thrombotic syndrome (intermediate, 6 months to under 5 years after treatment) | RR 0.74 [0.55, 1] | 1 study · 189 participants | Moderate Downgraded: imprecision |
Post‐thrombotic syndrome (late, 5 year | RR 0.6 [0.45, 0.79] | 1 study · 176 participants | Moderate Downgraded: imprecision |