Cochrane · systematic review · CD002062
Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
Hughes, RAC, Mehndiratta, MM, Rajabally, YA · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
2
Included studies
NR
No studies 2 · 16.7%Ungraded 0 · 0%Very low 4 · 33.3%Low 3 · 25%Moderate 3 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPrednisone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: people with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in disability after one year | no estimate extracted | NR | No studies |
Change in impairment after 12 weeks (excluding those who did not complete the study) NIS score (range 0 to 280) | no estimate extracted | 1 study · 28 participants | Very low Downgraded: risk of bias, imprecision |
Change in impairment after 12 weeks (including those who did not complete the study) NIS (range 0 to 280) | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Number of participants improved after 12 weeks (excluding those who did not complete the study) NIS score (range 0 to 280) | RR 2.4 | 1 study · 28 participants | Very low Downgraded: risk of bias, imprecision |
Number of participants improved after 12 weeks (including those who did not complete the study) NIS (range 0 to 280) | RR 2.02 | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Monthly pulsed high‐dose dexamethasone compared to oral prednisolone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: people with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in disability after one year Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | NR | No studies |
Remission at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.11 | 1 study · 40 participants | Moderate Downgraded: imprecision |
≥ 1 point improvement on INCAT disability score at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.24 | 1 study · 40 participants | Low Downgraded: imprecision, indirectness |
Change in impairment: change in MRC sum score at endpoint4 Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 39 participants | Low Downgraded: imprecision, indirectness |
Change in impairment: change in grip strength at endpoint4 Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 38 participants | Moderate Downgraded: imprecision |
Sleeplessness Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.44 | 1 study · 40 participants | Low Downgraded: imprecision, indirectness |
Moon facies Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.48 | 1 study · 40 participants | Moderate Downgraded: imprecision, indirectness |
Prednisone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: people with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in impairment after 12 weeks (excluding those who did not complete the study) Neuropathy impairment score (range 0 to 280) | no estimate extracted | 1 study · 28 participants | Very low Downgraded: risk of bias |
Improvement in impairment after 12 weeks (including those who did not complete the study) Neuropathy impairment score (range 0 to 280) | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias |
Number of patients improved after 12 weeks (excluding those who did not complete the study) Neuropathy impairment score (range 0 to 280) | RR 2.4 | 1 study · 28 participants | Very low Downgraded: risk of bias |
Number of patients who showed improvement after 12 weeks (including those who did not complete the study) Neuropathy impairment score (range 0 to 280) | RR 2.02 | 1 study · 35 participants | Very low Downgraded: risk of bias |
Monthly pulsed high‐dose dexamethasone compared to oral prednisolone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: people with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Remission at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.11 | 1 study · 40 participants | Moderate |
≥ 1 point improvement on INCAT disability score at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.24 | 1 study · 40 participants | Moderate |
Change in MRC sum score Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 39 participants | High |
Change in grip strength Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 38 participants | High |
Sleeplessness Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.44 | 1 study · 40 participants | High |
Moon facies Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.48 | 1 study · 40 participants | High |
Wide 95% CI. Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 participants | Ungraded |
Prednisone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: patients with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in impairment after 12 weeks (excluding those who did not complete the study) Neuropathy impairment score (range 0 to 280) | no estimate extracted | 1 study · 28 participants | Very low Downgraded: risk of bias |
Improvement in impairment after 12 weeks (including those who did not complete the study) Neuropathy impairment score (range 0 to 280) | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias |
Number of patients improved after 12 weeks (excluding those who did not complete the study) Neuropathy impairment score (range 0 to 280) | RR 2.4 | 1 study · 28 participants | Very low Downgraded: risk of bias |
Number of patients who showed improvement after 12 weeks (including those who did not complete the study) Neuropathy impairment score (range 0 to 280) | RR 2.02 | 1 study · 35 participants | Very low Downgraded: risk of bias |
Monthly pulsed high‐dose dexamethasone compared to oral prednisolone for chronic inflammatory demyelinating polyradiculoneuropathy
Population: patients with chronic inflammatory demyelinating polyradiculoneuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Remission at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.11 | 1 study · 40 participants | Moderate |
≥ 1 point improvement on INCAT disability score at 12 months Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 1.24 | 1 study · 40 participants | Moderate |
Change in MRC sum score Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 39 participants | High |
Change in grip strength Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 study · 38 participants | High |
Sleeplessness Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.44 | 1 study · 40 participants | High |
Moon facies Monthly pulsed high‐dose dexamethasone vs oral prednisolone | RR 0.48 | 1 study · 40 participants | High |
Wide 95% CI. Monthly pulsed high‐dose dexamethasone vs oral prednisolone | no estimate extracted | 1 participants | Ungraded |