Cochrane · systematic review · CD001798
Plasma exchange for Guillain‐Barré syndrome
Chevret, S, Hughes, RAC, Annane, D · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPlasma exchange compared to sham exchange or supportive treatment for Guillain‐Barré syndrome
Population: people with Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Walking with aid at 4 weeks Plasma exchange vs sham exchange or supportive treatment | RR 1.6 [1.19, 2.15] | 3 studies · 349 participants | Moderate Downgraded: risk of bias |
Dependency on a ventilator at 4 weeks Plasma exchange vs sham exchange or supportive treatment | RR 0.53 [0.39, 0.74] | 5 studies · 623 participants | Moderate Downgraded: risk of bias |
Full muscle strength recovery at 1 year Plasma exchange vs sham exchange or supportive treatment | RR 1.24 [1.07, 1.45] | 5 studies · 404 participants | Moderate Downgraded: risk of bias |
Relapses at 1 year Plasma exchange vs sham exchange or supportive treatment | RR 2.89 [1.05, 7.93] | 6 studies · 649 participants | Moderate Downgraded: risk of bias |
Deaths at 1 year Plasma exchange vs sham exchange or supportive treatment | RR 0.86 [0.45, 1.65] | 6 studies · 649 participants | High |
Severe infection Plasma exchange vs sham exchange or supportive treatment | RR 0.91 [0.73, 1.13] | 3 studies · 556 participants | Moderate Downgraded: risk of bias |
1Trials were not blinded. Plasma exchange vs sham exchange or supportive treatment | no estimate extracted | 1 participants | Ungraded |
Plasma exchange compared to sham exchange or supportive treatment for Guillain‐Barré syndrome
Population: patients with Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Walking or not with aid at 4 weeks Plasma exchange vs sham exchange or supportive treatment | RR 1.6 [1.19, 2.15] | 3 studies · 349 participants | Moderate Downgraded: risk of bias |
On or not on a ventilator at 4 weeks Plasma exchange vs sham exchange or supportive treatment | RR 0.53 [0.39, 0.74] | 5 studies · 623 participants | Moderate Downgraded: risk of bias |
Full muscle strength recovered or not at 1 year Plasma exchange vs sham exchange or supportive treatment | RR 1.24 [1.07, 1.45] | 5 studies · 404 participants | Moderate Downgraded: risk of bias |
Relapses at 6 to 12 months Plasma exchange vs sham exchange or supportive treatment | RR 2.89 [1.05, 7.93] | 6 studies · 649 participants | Moderate Downgraded: risk of bias |
Deaths at 1 year Plasma exchange vs sham exchange or supportive treatment | RR 0.86 [0.45, 1.65] | 6 studies · 649 participants | Moderate Downgraded: risk of bias |
Severe infection Plasma exchange vs sham exchange or supportive treatment | RR 0.91 [0.73, 1.13] | 3 studies · 556 participants | Moderate Downgraded: risk of bias |