Cochrane · systematic review · CD001301

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with normal total sperm count and motility

Cutting, E, Horta, F, Dang, V, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Gynaecology and Fertility2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 25%Moderate 6 · 75%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table ‐ ICSI compared to c‐IVF for males presenting with normal total sperm count and motility.

Population: : Couples with males presenting normal total sperm count and motility were included in this review.

CD001301.PUB2 (current) · 8 questions

Outcome	Effect	Evidence	Status / GRADE
Live Birth Summary of findings table ‐ ICSI vs c‐IVF	RR 1.11 [0.94, 1.3]	2 studies · 1124 participants	Low Downgraded: risk of bias, imprecision
Multiple Pregnancy Summary of findings table ‐ ICSI vs c‐IVF	RR 0.89 [0.66, 1.2]	2 studies · 1479 participants	Moderate Downgraded: imprecision
Ectopic Pregnancy Summary of findings table ‐ ICSI vs c‐IVF	RR 1 [0.42, 2.38]	1 study · 1064 participants	Moderate Downgraded: imprecision
Pre‐Eclampsia Summary of findings table ‐ ICSI vs c‐IVF	RR 1 [0.06, 15.95]	1 study · 1064 participants	Moderate Downgraded: imprecision
Prematurity Summary of findings table ‐ ICSI vs c‐IVF	RR 0.75 [0.53, 1.06]	1 study · 1064 participants	Moderate Downgraded: imprecision
Clinical Pregnancy Summary of findings table ‐ ICSI vs c‐IVF	RR 1 [0.88, 1.13]	3 studies · 1539 participants	Low Downgraded: risk of bias, imprecision
Viable intrauterine Pregnancy Summary of findings table ‐ ICSI vs c‐IVF	RR 1 [0.86, 1.16]	2 studies · 1479 participants	Moderate Downgraded: imprecision
Miscarriage Summary of findings table ‐ ICSI vs c‐IVF	RR 0.96 [0.58, 1.61]	1 study · 1064 participants	Moderate Downgraded: imprecision

ICSI compared to IVF for patients with non‐male subfertility

Population: couples with non‐male subfertility

CD001301 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Pregnancy rate ICSI vs IVF	OR 1.45 [0.95, 2.22]	1 study · 415 participants	Moderate Downgraded: risk of bias