Cochrane · systematic review · CD001241
Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants
Oddie, SJ, Young, L, McGuire, W · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySlow compared with faster rates of enteral feed advancement for preventing necrotising enterocolitis in very preterm or very low birth weight infants
Population: very preterm or very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Necrotising enterocolitis before hospital discharge Slow vs faster rates of enteral feed advancement | RR 1.06 [0.83, 1.37] | 14 studies · 4026 participants | Moderate Downgraded: risk of bias |
Mortality before hospital discharge Slow vs faster rates of enteral feed advancement | RR 1.13 [0.91, 1.39] | 13 studies · 3860 participants | Moderate Downgraded: risk of bias |
Feed intolerance before hospital discharge Slow vs faster rates of enteral feed advancement | RR 1.18 | 9 studies · 719 participants | Low Downgraded: risk of bias, imprecision |
Invasive infection before hospital discharge Slow vs faster rates of enteral feed advancement | RR 1.14 [0.99, 1.31] | 11 studies · 3583 participants | Low Downgraded: risk of bias, imprecision |
Slow compared with faster rates of enteral feed advancement for preventing necrotising enterocolitis in very preterm or very low birth weight infants
Population: very preterm or very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of necrotising enterocolitis ‐ All infants Slow vs faster rates of enteral feed advancement | RR 1.07 [0.83, 1.39] | 10 studies · 3738 participants | Moderate |
Mortality ‐ All infants Slow vs faster rates of enteral feed advancement | RR 1.15 [0.93, 1.42] | 9 studies · 3553 participants | Moderate |
Feed intolerance (causing interruption of enteral feeding) Slow vs faster rates of enteral feed advancement | RR 1.2 [0.95, 1.5] | 7 studies · 606 participants | Moderate |
Incidence of invasive infection Slow vs faster rates of enteral feed advancement | RR 1.15 [1, 1.32] | 8 studies · 3391 participants | Low |