Cochrane · systematic review · CD001150
Topical emollient for preventing infection in preterm infants
Cleminson, J, McGuire, W · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 25%Low 6 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyTopical ointment or cream versus routine skin care for preventing infection in preterm infants
Population: preterm (< 37 weeks') and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infection until hospital discharge Topical ointment or cream vs routine skin care | RR 1.13 [0.97, 1.31] | 8 studies · 2086 participants | Low Downgraded: risk of bias, imprecision |
Mortality until hospital discharge (or latest reported) Topical ointment or cream vs routine skin care | RR 0.87 [0.75, 1.03] | 7 studies · 2067 participants | Low Downgraded: risk of bias, imprecision |
Topical oil versus routine skin care for preterm infants
Population: preterm (< 37 weeks) and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infectionuntil hospital discharge Topical oil vs routine skin care | RR 0.71 [0.52, 0.96] | 9 studies · 3256 participants | Low Downgraded: risk of bias, inconsistency |
Mortality until hospital discharge (or latest reported) Topical oil vs routine skin care | RR 0.94 [0.82, 1.08] | 11 studies · 1119 participants | Low Downgraded: risk of bias, imprecision |
Topical ointment or cream versus oil for preterm infants
Population: preterm (< 37 weeks) and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infectionuntil hospital discharge Topical ointment or cream vs oil | RR 0.91 [0.57, 1.46] | 1 study · 316 participants | Low Downgraded: risk of bias, imprecision |
Mortality until hospital discharge (or latest reported) Topical ointment or cream vs oil | RR 0.82 [0.68, 0.98] | 1 study · 316 participants | Low Downgraded: risk of bias, imprecision |
Topical oil versus another oil for preterm infants
Population: preterm (< 37 weeks) and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infectionuntil hospital discharge Topical oil vs another oil | no estimate extracted | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Mortality until hospital discharge (or latest reported) Topical oil vs another oil | no estimate extracted | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Topical ointment or cream versus routine skin care for preventing infection in preterm infants
Population: Preterm (< 37 weeks') and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infection (any organism) Topical ointment or cream vs routine skin care | RR 1.13 [0.97, 1.31] | 8 studies · 2098 participants | Low Downgraded: risk of bias, inconsistency |
Mortality Topical ointment or cream vs routine skin care | RR 0.87 [0.75, 1.03] | 7 studies · 2067 participants | Low Downgraded: risk of bias, inconsistency |
Topical oil versus routine skin care for preterm and low birth weight infants
Population: Preterm (< 37 weeks) and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infection (any organism) Topical oil vs routine skin care | RR 0.71 | 6 studies · 844 participants | Low Downgraded: risk of bias, inconsistency |
Mortality Topical oil vs routine skin care | RR 0.94 [0.81, 1.08] | 9 studies · 1002 participants | Moderate Downgraded: risk of bias, inconsistency |
Topical ointment or cream versus routine skin care for preventing infection in preterm infants
Population: Preterm (< 37 weeks') and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infection (any organism) Topical ointment or cream vs routine skin care | RR 1.13 [0.97, 1.31] | 8 studies · 2098 participants | Low Downgraded: risk of bias, inconsistency |
Mortality Topical ointment or cream vs routine skin care | RR 0.87 [0.75, 1.03] | 7 studies · 2067 participants | Low Downgraded: risk of bias, inconsistency |
Topical oil versus routine skin care for preterm and low birth weight infants
Population: Preterm (< 37 weeks) and low birth weight (< 2500 g) infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Invasive infection (any organism) Topical oil vs routine skin care | RR 0.71 | 6 studies · 844 participants | Low Downgraded: risk of bias, inconsistency |
Mortality Topical oil vs routine skin care | RR 0.94 [0.81, 1.08] | 9 studies · 1002 participants | Moderate Downgraded: risk of bias, inconsistency |