Cochrane · systematic review · CD001146
Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants
Doyle, LW, Cheong, JL, Hay, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 16.7%High 5 · 83.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyEarly systemic postnatal corticosteroids compared with placebo or no treatment for preventing bronchopulmonary dysplasia in preterm infants
Population: preventing bronchopulmonary dysplasia in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at latest reported age Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.95 [0.85, 1.06] | 31 studies · 4373 participants | High |
BPD (36 weeks' PMA) Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.8 [0.73, 0.88] | 26 studies · 4167 participants | Moderate Downgraded: risk of bias, publication bias |
Mortality or BPD at 36 weeks' PMA Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.89 [0.84, 0.94] | 26 studies · 4167 participants | High |
Gastrointestinal perforation during primary hospitalisation Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.84 [1.36, 2.49] | 16 studies · 3040 participants | High |
Cerebral palsy at latest reported age Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.42 [1.06, 1.91] | 13 studies · 1973 participants | High |
Mortality or cerebral palsy at latest reported age Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.03 [0.91, 1.16] | 13 studies · 1973 participants | High |
Early systemic postnatal corticosteroids compared with placebo or no treatment for preventing bronchopulmonary dysplasia in preterm infants
Population: preventing bronchopulmonary dysplasia in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at 36 weeks Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.01 [0.89, 1.14] | 20 studies · 3733 participants | High |
Mortality at latest reported age Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.95 [0.85, 1.06] | 31 studies · 4373 participants | Moderate Downgraded: risk of bias, publication bias |
BPD (36 weeks) Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.79 [0.72, 0.87] | 24 studies · 3929 participants | Moderate Downgraded: risk of bias, inconsistency, publication bias |
Death or BPD at 36 weeks Early systemic postnatal corticosteroids vs placebo or no treatment | RR 0.88 [0.83, 0.93] | 25 studies · 3960 participants | Moderate Downgraded: risk of bias, inconsistency, publication bias |
Gastrointestinal perforation Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.72 [1.29, 2.3] | 16 studies · 3040 participants | High |
Cerebral palsy Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.42 [1.06, 1.91] | 13 studies · 1973 participants | High |
Death or cerebral palsy Early systemic postnatal corticosteroids vs placebo or no treatment | RR 1.03 [0.91, 1.16] | 13 studies · 1973 participants | Moderate Downgraded: risk of bias, inconsistency, publication bias |