Cochrane · systematic review · CD001145
Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants
Doyle, LW, Cheong, JL, Hay, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 40%High 3 · 60%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySystemic corticosteroids (dexamethasone or hydrocortisone) compared with control (placebo or nothing) for chronic lung disease in preterm infants
Population: preterm infants with chronic lung disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.81 [0.66, 0.99] | 21 studies · 1428 participants | High |
BPD at 36 weeks' PMA Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.89 [0.8, 0.99] | 14 studies · 988 participants | Moderate Downgraded: publication bias |
Mortality or BPD at 36 weeks' PMA Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.85 [0.79, 0.92] | 14 studies · 988 participants | Moderate Downgraded: inconsistency, publication bias |
Cerebral palsy ‐ at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 1.17 [0.84, 1.61] | 17 studies · 1290 participants | High |
Mortality or cerebral palsy ‐ at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.9 [0.76, 1.06] | 17 studies · 1290 participants | High |
Systemic corticosteroids (dexamethasone or hydrocortisone) compared with control (placebo or nothing) for chronic lung disease in preterm infants
Population: preterm infants with chronic lung disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at 36 weeks Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.82 [0.5, 1.35] | 7 studies · 360 participants | High |
Mortality at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.84 [0.66, 1.07] | 19 studies · 1035 participants | High |
BPD at 36 weeks Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.77 [0.67, 0.88] | 11 studies · 580 participants | Moderate Downgraded: publication bias |
Home on oxygen Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.71 [0.54, 0.94] | 7 studies · 611 participants | High |
Death or BPD at 36 weeks Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.77 [0.7, 0.86] | 11 studies · 580 participants | High |
Cerebral palsy ‐ at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 1.16 [0.82, 1.64] | 16 studies · 919 participants | High |
Death or cerebral palsy ‐ at latest reported age Systemic corticosteroids (dexamethasone or hydrocortisone) vs control (placebo or nothing) | RR 0.95 [0.78, 1.15] | 16 studies · 919 participants | High |