Cochrane · systematic review · CD001122
Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome
Bordewijk, EM, Ng, KYB, Rakic, L, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
9
No studies
2
Included studies
NR
No studies 2 · 18.2%Ungraded 0 · 0%Very low 2 · 18.2%Low 6 · 54.5%Moderate 1 · 9.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyLOD with and without medical ovulation compared to medical ovulation induction alone
Population: women with anovulatory PCOS and CC resistance
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth LOD with and without medical ovulation vs medical ovulation induction alone | OR 0.71 [0.54, 0.92] | 9 studies · 1015 participants | Low Downgraded: risk of bias |
Live birth (sensitivity analysis) LOD with and without medical ovulation vs medical ovulation induction alone | OR 0.9 [0.59, 1.36] | 4 studies · 415 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy LOD with and without medical ovulation vs medical ovulation induction alone | Peto OR 0.34 [0.18, 0.66] | 14 studies · 1161 participants | Moderate Downgraded: risk of bias, imprecision |
Clincial pregnancy LOD with and without medical ovulation vs medical ovulation induction alone | OR 0.86 [0.72, 1.03] | 21 studies · 2016 participants | Low Downgraded: risk of bias |
Miscarriage LOD with and without medical ovulation vs medical ovulation induction alone | Peto OR 1.11 [0.78, 1.59] | 19 studies · 1909 participants | Low Downgraded: risk of bias |
OHSS LOD with and without medical ovulation vs medical ovulation induction alone | Peto OR 0.25 [0.07, 0.91] | 8 studies · 722 participants | Low Downgraded: risk of bias, imprecision |
LOD of one ovary (unilateral) versus LOD of both ovaries (bilateral)
Population: women with anovulatory PCOS and CC resistance
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth LOD of one ovary (unilateral) vs LOD of both ovaries (bilateral) | OR 0.83 [0.24, 2.78] | 1 study · 44 participants | Very low Downgraded: risk of bias |
Multiple pregnancy LOD of one ovary (unilateral) vs LOD of both ovaries (bilateral) | no estimate extracted | NR | No studies |
Clinical pregnancy LOD of one ovary (unilateral) vs LOD of both ovaries (bilateral) | OR 0.57 [0.39, 0.84] | 7 studies · 470 participants | Low Downgraded: risk of bias |
Miscarriage LOD of one ovary (unilateral) vs LOD of both ovaries (bilateral) | Peto OR 1.02 [0.31, 3.33] | 2 studies · 131 participants | Very low Downgraded: risk of bias |
OHSS LOD of one ovary (unilateral) vs LOD of both ovaries (bilateral) | no estimate extracted | NR | No studies |
LOD with and without medical ovulation compared to other treatment for anovulatory women with PCOS
Population: patients with anovulatory women with PCOS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate LOD with and without medical ovulation vs other treatment | OR 0.77 [0.59, 1.01] | 8 studies · 1034 participants | Moderate Downgraded: risk of bias |
Pregnancy rate per woman randomised LOD with and without medical ovulation vs other treatment | OR 0.94 [0.78, 1.14] | 18 studies · 1930 participants | Low Downgraded: risk of bias |
Miscarriage rate LOD with and without medical ovulation vs other treatment | OR 1.1 [0.74, 1.61] | 15 studies · 1592 participants | Low Downgraded: risk of bias |
Multiple pregnancy rate (per ongoing pregnancy) LOD with and without medical ovulation vs other treatment | OR 0.21 [0.08, 0.58] | 12 studies · 1129 participants | Moderate Downgraded: risk of bias |
OHSS LOD with and without medical ovulation vs other treatment | OR 0.14 [0.02, 1.19] | 7 studies · 908 participants | Low Downgraded: risk of bias |
Unilateral ovarian drilling compared to bilateral ovarian drilling for anovulatory women with PCOS
Population: patients with anovulatory women with PCOS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Unilateral ovarian drilling vs bilateral ovarian drilling | OR 0.83 [0.24, 2.78] | 1 study · 44 participants | Very low Downgraded: risk of bias |
Pregnancy rate (per patient) Unilateral ovarian drilling vs bilateral ovarian drilling | OR 1 [0.55, 1.83] | 5 studies · 182 participants | Low Downgraded: risk of bias |
Miscarriage Unilateral ovarian drilling vs bilateral ovarian drilling | OR 1.02 [0.31, 3.33] | 2 studies · 131 participants | Moderate Downgraded: risk of bias |