Cochrane · systematic review · CD000400
Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding
Bofill Rodriguez, M, Lethaby, A, Farquhar, C · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
27
current version
GRADE rated
17
No studies
10
Included studies
NR
No studies 10 · 37%Ungraded 0 · 0%Very low 0 · 0%Low 13 · 48.1%Moderate 4 · 14.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyNSAIDs versus placebo (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) NSAIDs vs placebo (control) | no estimate extracted | 1 study · 11 participants | Low Downgraded: imprecision |
Proportion of women with no subjective improvement in MBL NSAIDs vs placebo (control) | OR 0.08 [0.03, 0.18] | 1 study · 80 participants | Low Downgraded: risk of bias, imprecision |
Quality of life NSAIDs vs placebo (control) | no estimate extracted | NR | No studies |
Number of days' bleeding NSAIDs vs placebo (control) | no estimate extracted | NR | No studies |
NSAIDs versus tranexamic acid (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) alkaline haematin method NSAIDs vs tranexamic acid (control) | no estimate extracted | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision |
Proportion of women with no subjective improvement in MBL NSAIDs vs tranexamic acid (control) | OR 1.44 [0.45, 4.61] | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision |
Number of days' bleeding NSAIDs vs tranexamic acid (control) | no estimate extracted | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision |
Quality of life NSAIDs vs tranexamic acid (control) | no estimate extracted | NR | No studies |
NSAIDs versus ethamsylate (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL at Rx (mL/cycle) NSAIDs vs ethamsylate (control) | no estimate extracted | 2 studies · 82 participants | Moderate Downgraded: risk of bias |
Proportion of women with no subjective improvement in MBL NSAIDs vs ethamsylate (control) | OR 0.7 [0.23, 2.12] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Number of days' bleeding NSAIDs vs ethamsylate (control) | no estimate extracted | 1 study · 46 participants | Low Downgraded: risk of bias, imprecision |
Quality of life NSAIDs vs ethamsylate (control) | no estimate extracted | NR | No studies |
NSAIDs versus danazol (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) NSAIDs vs danazol (control) | no estimate extracted | 3 studies · 79 participants | Moderate Downgraded: risk of bias |
Number of days' bleeding NSAIDs vs danazol (control) | no estimate extracted | 2 studies · 53 participants | Moderate Downgraded: risk of bias |
Quality of life NSAIDs vs danazol (control) | no estimate extracted | NR | No studies |
NSAIDs versus oral progestogens (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) NSAIDs vs oral progestogens (control) | no estimate extracted | 2 studies · 48 participants | Low Downgraded: risk of bias, inconsistency |
Number of days' bleeding NSAIDs vs oral progestogens (control) | no estimate extracted | 2 studies · 48 participants | Moderate Downgraded: risk of bias |
Quality of life NSAIDs vs oral progestogens (control) | no estimate extracted | NR | No studies |
NSAIDs versus progesterone‐releasing intrauterine system (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) NSAIDs vs progesterone‐releasing intrauterine system (control) | no estimate extracted | 1 study · 16 participants | Low Downgraded: risk of bias, imprecision |
Number of days' bleeding NSAIDs vs progesterone‐releasing intrauterine system (control) | no estimate extracted | 1 study · 16 participants | Low Downgraded: risk of bias, imprecision |
Quality of life NSAIDs vs progesterone‐releasing intrauterine system (control) | no estimate extracted | NR | No studies |
NSAIDs versus oral contraceptive pill (control)
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) NSAIDs vs oral contraceptive pill (control) | no estimate extracted | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Quality of life NSAIDs vs oral contraceptive pill (control) | no estimate extracted | NR | No studies |
Days of bleeding NSAIDs vs oral contraceptive pill (control) | no estimate extracted | NR | No studies |
Mefenamic acid compared to naproxen for heavy menstrual bleeding
Population: women with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL/cycle) Mefenamic acid vs naproxen | no estimate extracted | 2 studies · 61 participants | Low Downgraded: risk of bias, imprecision |
Number of days' bleeding Mefenamic acid vs naproxen | no estimate extracted | 1 study · 35 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Mefenamic acid vs naproxen | no estimate extracted | NR | No studies |
NSAIDs versus placebo (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) NSAIDs vs placebo (control) | no estimate extracted | 1 study · 11 participants | Low |
Proportion with no subjective improvement in MBL NSAIDs vs placebo (control) | OR 0.08 [0.03, 0.18] | 1 study · 80 participants | Low |
NSAIDs versus tranexamic acid (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) alkaline haematin method NSAIDs vs tranexamic acid (control) | no estimate extracted | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision |
Proportion with no subjective improvement in MBL NSAIDs vs tranexamic acid (control) | OR 1.44 [0.45, 4.61] | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision |
Duration of menstruation (days) NSAIDs vs tranexamic acid (control) | no estimate extracted | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision |
NSAIDs versus ethamsylate (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL at Rx (mL per cycle) NSAIDs vs ethamsylate (control) | no estimate extracted | 2 studies · 82 participants | Moderate Downgraded: risk of bias, imprecision |
Proportion with no subjective improvement in MBL NSAIDs vs ethamsylate (control) | OR 0.7 [0.23, 2.12] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Duration of menstruation (days) NSAIDs vs ethamsylate (control) | no estimate extracted | 1 study · 46 participants | Low Downgraded: risk of bias, imprecision |
NSAIDs versus danazol (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) NSAIDs vs danazol (control) | no estimate extracted | 3 studies · 79 participants | Moderate Downgraded: risk of bias |
Duration of menstruation (days) NSAIDs vs danazol (control) | no estimate extracted | 2 studies · 53 participants | Moderate Downgraded: risk of bias |
NSAIDs versus oral progestogens (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) NSAIDs vs oral progestogens (control) | no estimate extracted | 2 studies · 48 participants | Low Downgraded: risk of bias |
Duration of bleeding (days) NSAIDs vs oral progestogens (control) | no estimate extracted | 2 studies · 48 participants | Moderate Downgraded: risk of bias |
NSAIDs versus progesterone‐releasing intrauterine system (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) NSAIDs vs progesterone‐releasing intrauterine system (control) | no estimate extracted | 1 study · 16 participants | Low Downgraded: risk of bias, imprecision |
Duration of menstruation (days) NSAIDs vs progesterone‐releasing intrauterine system (control) | no estimate extracted | 1 study · 16 participants | Low Downgraded: risk of bias, imprecision |
NSAIDs versus oral contraceptive pill (control)
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) NSAIDs vs oral contraceptive pill (control) | no estimate extracted | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Mefenamic acid compared to naproxen for heavy menstrual bleeding
Population: patients with heavy menstrual bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
MBL (mL per cycle) Mefenamic acid vs naproxen | no estimate extracted | 2 studies · 61 participants | Low Downgraded: risk of bias |
Duration of menstruation (days) Mefenamic acid vs naproxen | no estimate extracted | 1 study · 35 participants | Low |