Cochrane · systematic review · CD000343
Multi‐nutrient fortification of human milk for preterm infants
Brown, JV, Lin, L, Embleton, ND, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMulti‐nutrient fortification of human milk for preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/kg/d) | no estimate extracted | 14 studies · 951 participants | Low Downgraded: inconsistency |
Length gain (cm/week) | no estimate extracted | 10 studies · 741 participants | Low Downgraded: inconsistency |
Head growth (cm/week) | no estimate extracted | 11 studies · 821 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Mental development index (MDI) at 18 months | no estimate extracted | 1 study · 245 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Psychomotor development index (PDI) at 18 months | no estimate extracted | 1 study · 245 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Necrotising enterocolitis | RR 1.37 [0.72, 2.63] | 13 studies · 1110 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Multi‐nutrient fortification of human milk for preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/kg/d) | no estimate extracted | 10 studies · 635 participants | Low Downgraded: inconsistency |
Length gain (cm/wk) | no estimate extracted | 8 studies · 555 participants | Low Downgraded: inconsistency |
Head growth (cm/wk) | no estimate extracted | 8 studies · 555 participants | Moderate Downgraded: risk of bias, inconsistency |
Mental development index (MDI) at 18 months | no estimate extracted | 1 study · 245 participants | Moderate Downgraded: risk of bias, inconsistency |
Psychomotor development index (PDI) at 18 months | no estimate extracted | 1 study · 245 participants | Moderate Downgraded: risk of bias, inconsistency |
Necrotising enterocolitis | RR 1.57 [0.76, 3.23] | 11 studies · 882 participants | Low Downgraded: risk of bias, inconsistency |