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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

Outcome

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Review versions

2,434 questions in 139 reviews · Kidney and Transplant

current versions

No studies 504 · 20.7%Ungraded 40 · 1.6%Very low 611 · 25.1%Low 790 · 32.5%Moderate 414 · 17%High 75 · 3.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Antiviral prophylaxis vs placebo or no treatment CMV disease: all symptomatic CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.42 [0.34, 0.52]	19 studies · 1981 participants	High
Ganciclovir vs aciclovir Death due to CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.33 [0.07, 1.58]	6 studies · 832 participants	Moderate
Ganciclovir vs aciclovir All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.13 [0.82, 1.58]	8 studies · 1138 participants	Moderate
Ganciclovir vs aciclovir Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.98 [0.87, 1.1]	6 studies · 1009 participants	High
Ganciclovir vs aciclovir Graft loss · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.55 [0.27, 1.13]	3 studies · 268 participants	Moderate
Ganciclovir vs aciclovir Opportunistic infections: other viral infections · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.81 [0.32, 2.01]	4 studies · 740 participants	Moderate
Ganciclovir vs aciclovir Leucopenia · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 3.28 [1.48, 7.25]	6 studies · 955 participants	Low
Ganciclovir vs aciclovir Kidney dysfunction · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.96 [0.83, 1.1]	4 studies · 661 participants	Moderate
Valaciclovir vs ganciclovir or valganciclovir CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.55 [0.17, 1.74]	4 studies · 331 participants	Low
Valaciclovir vs ganciclovir or valganciclovir All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.97 [0.31, 12.37]	3 studies · 273 participants	Low
Valaciclovir vs ganciclovir or valganciclovir CMV infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.31 [0.91, 1.9]	4 studies · 331 participants	Low
Antiviral prophylaxis vs placebo or no treatment Death due to CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.26 [0.08, 0.78]	7 studies · 1300 participants	Moderate
Valaciclovir vs ganciclovir or valganciclovir Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.91 [0.22, 3.73]	3 studies · 271 participants	Very low
Valaciclovir vs ganciclovir or valganciclovir Graft loss · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.61 [0.18, 2.02]	2 studies · 190 participants	Low
Valaciclovir vs ganciclovir or valganciclovir Leucopenia · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.74 [0.45, 1.24]	2 studies · 188 participants	Moderate
Valaciclovir vs ganciclovir or valganciclovir SCr at the end of · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	no estimate extracted	3 studies · 271 participants	Moderate
Extended vs short‐duration valganciclovir CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.2 [0.12, 0.35]	2 studies · 454 participants	Moderate
Extended vs short‐duration valganciclovir All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.09 [0.01, 1.7]	1 study · 319 participants	Low
Extended vs short‐duration valganciclovir CMV syndrome · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.39 [0.24, 0.64]	2 studies · 454 participants	Moderate
Extended vs short‐duration valganciclovir CMV infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.27 [0.1, 0.71]	2 studies · 454 participants	Low
Extended vs short‐duration valganciclovir Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.64 [0.43, 0.95]	2 studies · 454 participants	Moderate
Extended vs short‐duration valganciclovir Opportunistic infections · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.71 [0.33, 1.57]	2 studies · 456 participants	Low
Antiviral prophylaxis vs placebo or no treatment All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.63 [0.43, 0.92]	17 studies · 1838 participants	High
Extended vs short‐duration valganciclovir Total treatment‐related adverse effects · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.16 [0.97, 1.4]	2 studies · 456 participants	Moderate
Low vs standard dose valganciclovir All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.2 [0.11, 4.11]	1 study · 196 participants	Low
Low vs standard dose valganciclovir CMV infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.37 [0.11, 1.22]	2 studies · 256 participants	Low
Low vs standard dose valganciclovir Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.33 [0.07, 1.61]	1 study · 196 participants	Low
Low vs standard dose valganciclovir Graft loss · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1 [0.06, 15.76]	1 study · 196 participants	Low
Low vs standard dose valganciclovir Opportunistic infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	no estimate extracted	NR	No studies
Low vs standard dose valganciclovir Adverse events · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	no estimate extracted	NR	No studies
Maribavir vs ganciclovir CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.3 [0.74, 2.29]	1 study · 233 participants	Low
Maribavir vs ganciclovir All‐cause death · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.5 [0.55, 4.11]	1 study · 294 participants	Low
Maribavir vs ganciclovir CMV infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.34 [1.1, 1.65]	1 study · 233 participants	Moderate
Antiviral prophylaxis vs placebo or no treatment CMV infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.61 [0.48, 0.77]	17 studies · 1786 participants	High
Maribavir vs ganciclovir Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.92 [0.53, 1.61]	1 study · 303 participants	Low
Maribavir vs ganciclovir Graft loss · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	no estimate extracted	NR	No studies
Maribavir vs ganciclovir Opportunistic infection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	no estimate extracted	NR	No studies
Maribavir vs ganciclovir Adverse events · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.99 [0.79, 1.25]	1 study · 303 participants	Moderate
Antiviral prophylaxis vs placebo or no treatment Graft loss · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.74 [0.47, 1.17]	10 studies · 825 participants	Moderate
Antiviral prophylaxis vs placebo or no treatment Acute rejection · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.9 [0.78, 1.05]	13 studies · 1420 participants	High
Antiviral prophylaxis vs placebo or no treatment Leucopenia · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.03 [0.67, 1.59]	4 studies · 1125 participants	Moderate
Antiviral prophylaxis vs placebo or no treatment Kidney dysfunction · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 1.81 [0.88, 3.73]	5 studies · 668 participants	Low
Ganciclovir vs aciclovir CMV disease · solid organ transplant recipients Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients (2024) · Cochrane	RR 0.37 [0.23, 0.6]	7 studies · 1113 participants	High
Renin‐angiotensin system inhibition vs placebo or no treatment Death (any cause) · people with IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Renin‐angiotensin system inhibition vs other supportive care treatment Remission of proteinuria · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Renin‐angiotensin system inhibition vs other supportive care treatment Remission of haematuria · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Renin‐angiotensin system inhibition vs other supportive care treatment Relapse of proteinuria · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	NR	No studies
Renin‐angiotensin system inhibition vs other supportive care treatment > 50% increase in SCr · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	RR 0.23 [0.07, 0.7]	1 study · 44 participants	Low
Renin‐angiotensin system inhibition vs other supportive care treatment Proteinuria · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	3 studies · 168 participants	Moderate
Tonsillectomy plus standard care vs standard care Death (any cause) · people IgA nephropathy Non‐immunosuppressive treatment for IgA nephropathy (2024) · Cochrane	no estimate extracted	NR	No studies