Cochrane · systematic review · CD003962
Non‐immunosuppressive treatment for IgA nephropathy
Tunnicliffe, DJ, Reid, S, Craig, JC, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
22
current version
GRADE rated
11
No studies
11
Included studies
NR
No studies 11 · 50%Ungraded 0 · 0%Very low 2 · 9.1%Low 7 · 31.8%Moderate 2 · 9.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Renin‐angiotensin system inhibition compared to placebo or no treatment for people with IgA nephropathy
Population: people with IgA nephropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (any cause) Renin‐angiotensin system inhibition vs placebo or no treatment | no estimate extracted | NR | No studies |
Kidney failure or doubling of SCr Renin‐angiotensin system inhibition vs placebo or no treatment | RR 0.25 [0.03, 2.21] | 1 study · 109 participants | Low Downgraded: imprecision |
Remission of proteinuria: complete remission Renin‐angiotensin system inhibition vs placebo or no treatment | RR 5.29 [0.27, 102.49] | 1 study · 33 participants | Low Downgraded: imprecision |
Remission of haematuria Renin‐angiotensin system inhibition vs placebo or no treatment | no estimate extracted | NR | No studies |
Relapse of proteinuria Renin‐angiotensin system inhibition vs placebo or no treatment | no estimate extracted | NR | No studies |
> 50% increase in SCr Renin‐angiotensin system inhibition vs placebo or no treatment | no estimate extracted | NR | No studies |
Proteinuria Renin‐angiotensin system inhibition vs placebo or no treatment | no estimate extracted | 4 studies · 199 participants | Moderate Downgraded: risk of bias, imprecision |
Renin‐angiotensin system inhibition compared to other supportive care treatment for IgA nephropathy
Population: people IgA nephropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Renin‐angiotensin system inhibition vs other supportive care treatment | no estimate extracted | NR | No studies |
Kidney failure Renin‐angiotensin system inhibition vs other supportive care treatment | RR 0.2 [0.01, 3.88] | 1 study · 34 participants | Very low Downgraded: risk of bias |
Remission of proteinuria Renin‐angiotensin system inhibition vs other supportive care treatment | no estimate extracted | NR | No studies |
Remission of haematuria Renin‐angiotensin system inhibition vs other supportive care treatment | no estimate extracted | NR | No studies |
Relapse of proteinuria Renin‐angiotensin system inhibition vs other supportive care treatment | no estimate extracted | NR | No studies |
> 50% increase in SCr Renin‐angiotensin system inhibition vs other supportive care treatment | RR 0.23 [0.07, 0.7] | 1 study · 44 participants | Low Downgraded: risk of bias, imprecision |
Proteinuria Renin‐angiotensin system inhibition vs other supportive care treatment | no estimate extracted | 3 studies · 168 participants | Moderate Downgraded: risk of bias |
Tonsillectomy plus standard care compared to standard care for IgA nephropathy
Population: people IgA nephropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (any cause) Tonsillectomy plus standard care vs standard care | no estimate extracted | NR | No studies |
Kidney failure Tonsillectomy plus standard care vs standard care | no estimate extracted | NR | No studies |
Remission of proteinuria Tonsillectomy plus standard care vs standard care | RR 1.9 [1.45, 2.47] | 2 studies · 143 participants | Low Downgraded: risk of bias |
Remission of haematuria (microscopic) Tonsillectomy plus standard care vs standard care | RR 1.93 [1.47, 2.53] | 2 studies · 143 participants | Low Downgraded: risk of bias |
Relapse of haematuria (macroscopic) Tonsillectomy plus standard care vs standard care | RR 1.33 [0.8, 2.23] | 1 study · 32 participants | Very low Downgraded: risk of bias |
Relapse of proteinuria Tonsillectomy plus standard care vs standard care | RR 0.7 [0.57, 0.85] | 1 study · 73 participants | Low Downgraded: risk of bias |
> 50% increase in SCr Tonsillectomy plus standard care vs standard care | no estimate extracted | NR | No studies |
Proteinuria Tonsillectomy plus standard care vs standard care | no estimate extracted | 2 studies · 69 participants | Low Downgraded: risk of bias |