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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

487 questions in 49 reviews · Breast Cancer

current versions
No studies 44 · 9%Ungraded 14 · 2.9%Very low 108 · 22.2%Low 128 · 26.3%Moderate 107 · 22%High 86 · 17.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Shared decision‐making (all components) vs control
Satisfaction with the decision‐making process · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Knowledge of all the options · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extracted5 studies · 2114 participantsLow
Some components of shared decision‐making, including clarification of values and preferences, vs control
Adherence to the chosen option · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Choice of an option aligned with each woman’s values and preferences · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Woman's involvement · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Mental health outcomes · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
MD 0.542 studies · 749 participantsLow
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Satisfaction with the decision‐making process · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Confidence in the decision made · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
MD 2.892 studies · 1191 participantsLow
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Knowledge of all the options*** · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
MD 1.14 [0.61, 1.62]4 studies · 2510 participantsHigh
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Adherence to the chosen option · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Choice of an option aligned with each woman’s values and preferences · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making (all components) vs control
Confidence in the decision made · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Woman's involvement · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Studies focused only on enhanced communication, without clarification of values and preferences, vs control
Mental health outcomes · women aged 40 to 75 years old at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
MD 0.332 studies · 1193 participantsHigh
Shared decision‐making (all components) vs control
Knowledge of all the options · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
RR 1.18 [0.61, 2.28]1 study · 133 participantsVery low
Shared decision‐making (all components) vs control
Adherence to the chosen option · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making (all components) vs control
Choice of an option aligned with each woman’s values and preferences · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making (all components) vs control
Woman's involvement · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Shared decision‐making (all components) vs control
Mental health outcomes · women aged 40 to 75 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Satisfaction with the decision‐making process · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extractedNRNo studies
Some components of shared decision‐making, including clarification of values and preferences, vs control
Confidence in the decision made · women aged 38 to 71 years at average to moderate risk of breast cancer
Shared decision‐making for supporting women’s decisions about breast cancer screening (2024) · Cochrane
no estimate extracted4 studies · 1714 participantsVery low
Cognitive behavioural therapy vs control
DepressionHospital Anxiety and Depression Scale (HADS) or Beck Inventory Score (HADS score range from 0 to 21 and Beck Inventory Score range from 0 to 63) · Women with non‐metastatic breast cancer
Psychological interventions for women with non‐metastatic breast cancer (2023) · Cochrane
no estimate extracted27 studies · 3321 participantsLow
Cognitive behavioural therapy vs control
AnxietyHospital Anxiety Scale, STAI (State‐Trait Anxiety Inventory) · Women with non‐metastatic breast cancer
Psychological interventions for women with non‐metastatic breast cancer (2023) · Cochrane
no estimate extracted22 studies · 2702 participantsLow
Cognitive behavioural therapy vs control
Mood disturbanceProfile of mood state (higher score indicates more mood disturbance, score range from 0 to 200) · Women with non‐metastatic breast cancer
Psychological interventions for women with non‐metastatic breast cancer (2023) · Cochrane
no estimate extracted13 studies · 2276 participantsLow
Cognitive behavioural therapy vs control
Quality of lifeSeveral tools were used e.g. EORTC, FACT B, Medical outcomes, QoL Cancer Survivor · Women with non‐metastatic breast cancer
Psychological interventions for women with non‐metastatic breast cancer (2023) · Cochrane
no estimate extracted20 studies · 1747 participantsLow
Cognitive behavioural therapy vs control
Stress · Women with non‐metastatic breast cancer
Psychological interventions for women with non‐metastatic breast cancer (2023) · Cochrane
no estimate extracted8 studies · 564 participantsLow
Mammography in combination with breast ultrasonography vs mammography alone
Outcomes after 1‐ to 2‐year · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
no estimate extractedNRNo studies
Mammography in combination with breast ultrasonography vs mammography alone
False‐positive rate · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.43 [1.37, 1.5]1 study · 70825 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
False‐negative rate · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.39 [0.23, 0.66]1 study · 354 participantsModerate
Mammography in combination with breast ultrasonography vs mammography alone
Rate of biopsies · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 2.49 [2.28, 2.72]1 study · 72717 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
Outcomes after 1‐ to 2‐year · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
no estimate extractedNRNo studies
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection in women with dense breasts: RCT · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.65 [1, 2.72]1 study · 11390 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection in women with dense breasts: cohort studies · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.78 [1.23, 2.56]50327 participantsModerate
Mammography in combination with breast ultrasonography vs mammography alone
Incremental detection of invasive cancers · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.91 [0.67, 1.24]1 study · 65 participantsLow
Mammography in combination with breast ultrasonography vs mammography alone
Interval cancer · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.29 [0.08, 1.05]1 study · 11390 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
False‐positive rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.76 [1.58, 1.96]1 study · 11312 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
False‐negative rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.23 [0.07, 0.78]1 study · 78 participantsModerate
Mammography in combination with breast ultrasonography vs mammography alone
Breast cancer mortality · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
no estimate extractedNRNo studies
Mammography in combination with breast ultrasonography vs mammography alone
Biopsy rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 2.73 [2.24, 3.34]1 study · 11390 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
Outcomes after 1‐ to 2‐year · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
no estimate extractedNRNo studies
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection for women with non‐dense breasts: RCT · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.93 [1.01, 3.68]1 study · 7823 participantsModerate
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection for women with non‐dense breasts: cohort studies · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.13 [0.85, 1.49]40636 participantsLow
Mammography in combination with breast ultrasonography vs mammography alone
Interval cancer · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.22 [0.05, 1.03]1 study · 7823 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
False‐positive rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.36 [1.18, 1.56]1 study · 7771 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
False‐negative rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.18 [0.04, 0.74]1 study · 52 participantsModerate
Mammography in combination with breast ultrasonography vs mammography alone
Biopsy rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 2.58 [1.96, 3.4]1 study · 7823 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
All‐cause mortality · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
no estimate extractedNRNo studies
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection: RCT · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.54 [1.22, 1.94]1 study · 72717 participantsHigh
Mammography in combination with breast ultrasonography vs mammography alone
Incremental cancer detection: cohort studies · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 1.35 [0.92, 1.98]83469 participantsLow
Mammography in combination with breast ultrasonography vs mammography alone
Incremental detection of invasive cancers: RCT · s of women with dense and non‐dense breasts
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in… (2023) · Cochrane
RR 0.95 [0.82, 1.09]1 study · 301 participantsLow