Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

297 questions · 299 findings · 41 reviews · Neonatal · Headline outcomes only

No studies found 31 · 10.4%GRADE not reported 15 · 5%Very low 52 · 17.4%Low 116 · 38.8%Moderate 76 · 25.4%High 9 · 3%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention

Gestational age (preterm birth < 37 weeks) · preterm infants

Probiotics administered to pregnant women at risk of preterm birth showed no clear difference in preterm birth < 37 weeks' gestation compared with placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention

Miscarriage/stillbirth · preterm infants

Probiotics administered to pregnant women at risk of preterm birth showed no clear difference in miscarriage/stillbirth compared with placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Necrotising enterocolitis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in any necrotizing Enterocolitis (NEC) compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Mortality before hospital discharge · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in death prior to hospital discharge compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Death or NEC · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in death or NEC compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

NEC‐related surgery during study period · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in surgery for NEC compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Neonatal sepsis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in neonatal sepsis compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

BPD or death by it prior to 37 weeks' PMA (outcomes collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in BPD or death by it prior to 37 weeks' PMA (outcomes collected… compared with placebo (high certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

All‐cause mortality (outcome collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in all‐cause mortality (outcome collected through first event: death,… compared with placebo (moderate certainty).

1 finding from 1 review