Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
33 studies · 1848 participants
Very low

n3PUFAs vs placebo

Adverse events Study reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes adverse eventsStudy reports compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
OR 1.27 [0.99, 1.64]
24 studies · 1503 participants
Very low

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ remission) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ remission)Depressive… compared with placebo (low certainty).

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
OR 1.13 [0.74, 1.72]
8 studies · 609 participants
Low

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ response) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ response)Depressive… compared with placebo (low certainty).

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
OR 1.2 [0.8, 1.79]
17 studies · 794 participants
Low

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 476 participants
Very low

n3PUFAs vs placebo

Trial non‐completionStudy reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes trial non‐completionStudy reports compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids for depression in adults 2021 · Cochrane Headline outcomes only
OR 0.92 [0.7, 1.22]
29 studies · 1777 participants
Very low